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Tytuł pozycji:

PPARα Agonist, MHY3200, Alleviates Renal Inflammation during Aging via Regulating ROS/Akt/FoxO1 Signaling.

Tytuł:
PPARα Agonist, MHY3200, Alleviates Renal Inflammation during Aging via Regulating ROS/Akt/FoxO1 Signaling.
Autorzy:
Kim MJ; Department of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.
Kim DH; Department of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.
Bang E; Department of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.
Noh SG; Interdisciplinary Research Programme of Bioinformatics and Longevity Science, Department of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.
Chun P; College of Pharmacy, Inje University, Gimhae 50834, Gyeongsangnam-do, Korea.
Yokozawa T; Graduate School Science and Engineering for Research, University of Toyama, Toyama 930-8555, Japan.
Moon HR; Department of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.
Chung HY; Department of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 May 26; Vol. 26 (11). Date of Electronic Publication: 2021 May 26.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI, c1995-
MeSH Terms:
Acetates/*pharmacology
Aging/*drug effects
Inflammation/*drug therapy
Kidney/*drug effects
Nerve Tissue Proteins/*metabolism
PPAR alpha/*agonists
Proto-Oncogene Proteins c-akt/*metabolism
Thiazoles/*pharmacology
Acetates/therapeutic use ; Animals ; Body Weight ; Gene Expression Regulation ; Hypoglycemic Agents/pharmacology ; Insulin/metabolism ; Kidney/pathology ; Male ; PPAR alpha/metabolism ; Phosphorylation ; Protein Binding ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Thiazoles/therapeutic use ; Time Factors ; Triglycerides/metabolism
References:
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Contributed Indexing:
Keywords: Akt; MHY3200; NF-κB; ROS; aging; inflammation
Substance Nomenclature:
0 (Acetates)
0 (Hypoglycemic Agents)
0 (Insulin)
0 (MHY3200)
0 (Nerve Tissue Proteins)
0 (PPAR alpha)
0 (Reactive Oxygen Species)
0 (Thiazoles)
0 (Triglycerides)
0 (Foxo1 protein, rat)
EC 2.7.11.1 (Akt1 protein, rat)
EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
Entry Date(s):
Date Created: 20210602 Date Completed: 20210712 Latest Revision: 20221207
Update Code:
20240104
PubMed Central ID:
PMC8198004
DOI:
10.3390/molecules26113197
PMID:
34073584
Czasopismo naukowe
PPARα is a ligand-dependent transcription factor and its activation is known to play an important role in cell defense through anti-inflammatory and antioxidant effects. MHY3200 (2-[4-(5-chlorobenzo[ d ]thiazol-2-yl)phenoxy]-2,2-difluoroacetic acid), a novel benzothiazole-derived peroxisome proliferator-activated receptor α (PPARα) agonist, is a synthesized PPARα activator. This study examined the beneficial effects of MHY3200 on age-associated alterations in reactive oxygen species (ROS)/Akt/forkhead box (FoxO) 1 signaling in rat kidneys. Young (7-month-old) and old (22-month-old) rats were treated with MHY3200 (1 mg/kg body weight/day or 3 mg/kg body weight/day) for two weeks. MHY3200 treatment led to a notable decrease in triglyceride and insulin levels in serum from old rats. The elevated kidney ROS level, serum insulin level, and Akt phosphorylation in old rats were reduced following MHY3200 treatment; moreover, FoxO1 phosphorylation increased. MHY3200 treatment led to the increased level of FoxO1 and its target gene, MnSOD. MHY3200 suppressed cyclooxygenase-2 expression by activating PPARα and inhibiting the activation of nuclear factor-κB (NF-κB) in the kidneys of old rats. Our results suggest that MHY3200 ameliorates age-associated renal inflammation by regulating NF-κB and FoxO1 via ROS/Akt signaling.
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