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Tytuł pozycji:

Prevalence and risk factors for antibiotic utilization in Chinese children.

Tytuł:
Prevalence and risk factors for antibiotic utilization in Chinese children.
Autorzy:
Guo S; Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.; NHC Key Lab of Health Economics and Policy Research (Shandong University), Jinan, 250012, China.
Sun Q; Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.; NHC Key Lab of Health Economics and Policy Research (Shandong University), Jinan, 250012, China.
Zhao X; School of Nursing, China Medical University, Shenyang, 110100, China.
Shen L; Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.; NHC Key Lab of Health Economics and Policy Research (Shandong University), Jinan, 250012, China.
Zhen X; Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. .; NHC Key Lab of Health Economics and Policy Research (Shandong University), Jinan, 250012, China. .
Źródło:
BMC pediatrics [BMC Pediatr] 2021 Jun 01; Vol. 21 (1), pp. 255. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
Język:
English
Imprint Name(s):
Original Publication: London : BioMed Central, [2001-
MeSH Terms:
Anti-Bacterial Agents*/therapeutic use
Drug Utilization*
Child ; China/epidemiology ; Drug Resistance, Microbial ; Humans ; Prevalence ; Risk Factors
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Grant Information:
71774103 National Natural Science Foundation of China
Contributed Indexing:
Keywords: Antibiotic; Children; China; Prevalence; Risk factors
Substance Nomenclature:
0 (Anti-Bacterial Agents)
Entry Date(s):
Date Created: 20210602 Date Completed: 20210610 Latest Revision: 20210610
Update Code:
20240104
PubMed Central ID:
PMC8168021
DOI:
10.1186/s12887-021-02706-z
PMID:
34074254
Czasopismo naukowe
Background: Antibiotic resistance poses a significant threat to public health globally. Irrational utilization of antibiotics being one of the main reasons of antibiotic resistant. Children as a special group, there's more chance of getting infected. Although most of the infection is viral in etiology, antibiotics still are the most frequently prescribed medications for children. Therefore, high use of antibiotics among children raises concern about the appropriateness of antibiotic prescribing. This systematic review aims to measuring prevalence and risk factors for antibiotic utilization in children in China.
Methods: English and Chinese databases were searched to identify relevant studies evaluating the prevalence and risk factors for antibiotic utilization in Chinese children (0-18 years), which were published between 2010 and July 2020. A Meta-analysis of prevalence was performed using random effect model. The Agency for Healthcare Research and Quality (AHRQ) and modified Jadad score was used to assess risk of bias of studies. In addition, we explored the risk factors of antibiotic utilization in Chinese children using qualitative analysis.
Results: Of 10,075 studies identified, 98 eligible studies were included after excluded duplicated studies. A total of 79 studies reported prevalence and 42 studies reported risk factors for antibiotic utilization in children. The overall prevalence of antibiotic utilization among outpatients and inpatients were 63.8% (35 studies, 95% confidence interval (CI): 55.1-72.4%), and 81.3% (41 studies, 95% CI: 77.3-85.2%), respectively. In addition, the overall prevalence of caregiver's self-medicating of antibiotics for children at home was 37.8% (4 studies, 95% CI: 7.9-67.6%). The high prevalence of antibiotics was associated with multiple factors, while lacking of skills and knowledge in both physicians and caregivers was the most recognized risk factor, caregivers put pressure on physicians to get antibiotics and self-medicating with antibiotics at home for children also were the main factors attributed to this issue.
Conclusion: The prevalence of antibiotic utilization in Chinese children is heavy both in hospitals and home. It is important for government to develop more effective strategies to improve the irrational use of antibiotic, especially in rural setting.

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