Polymorphisms of rs2483205 and rs562556 in the PCSK9 gene are associated with coronary artery disease and cardiovascular risk factors.

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Abstrakt

Tytuł:: Polymorphisms of rs2483205 and rs562556 in the PCSK9 gene are associated with coronary artery disease and cardiovascular risk factors.
Autorzy:: Gai MT; Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, China.; College of Basic Medicine of Xinjiang Medical University, Urumqi, 830054, China.
Adi D; Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, China.; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China.
Chen XC; Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, China.
Liu F; Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, China.
Xie X; Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, China.; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China.
Yang YN; Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, China.; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China.
Gao XM; Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, China.
Ma X; Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, China.; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China.
Fu ZY; Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, China.; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China.
Ma YT; Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, China. .; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China. .
Chen BD; Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, China. .; College of Basic Medicine of Xinjiang Medical University, Urumqi, 830054, China. .
Źródło:: Scientific reports [Sci Rep] 2021 Jun 01; Vol. 11 (1), pp. 11450. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji:: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Haplotypes*
Polymorphism, Single Nucleotide*
Coronary Artery Disease/*genetics
Proprotein Convertase 9/*genetics
Aged ; Alleles ; Blood Glucose/metabolism ; Body Mass Index ; Cholesterol, LDL/blood ; Cholesterol, LDL/genetics ; Coronary Artery Disease/blood ; Female ; Humans ; Male ; Mean Platelet Volume ; Middle Aged ; Obesity/blood ; Obesity/genetics ; Risk Factors
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Substance Nomenclature:: 0 (Blood Glucose)
0 (Cholesterol, LDL)
EC 3.4.21.- (PCSK9 protein, human)
EC 3.4.21.- (Proprotein Convertase 9)
Entry Date(s):: Date Created: 20210602 Date Completed: 20211105 Latest Revision: 20211105
Update Code:: 20240104
PubMed Central ID:: PMC8169929
DOI:: 10.1038/s41598-021-90975-0
PMID:: 34075144
: Czasopismo naukowe

Pełny tekst

PCSK9 plays a crucial role in lipid metabolism. This case-control study explored the associations of novel single nucleotide polymorphisms (SNPs) of the PCSK9 gene with coronary artery disease (CAD) (≥ 1 coronary artery stenosis ≥ 50%) and its risk factors in the Han population in Xinjiang, China. Four tag SNPs (rs11583680, rs2483205, rs2495477 and rs562556) of the PCSK9 gene were genotyped in 950 CAD patients and 1082 healthy controls. The distributions of genotypes in rs2483205 and rs562556 were significantly different between the groups (all p < 0.05). The TT genotype of rs2483205, GG genotype of rs562556, and their H4 (T-G) haplotype were associated with CAD [odds ratio (OR) 0.65, confidence interval (CI) 0.45-0.95, p = 0.024; 0.63, 0.45-0.90, p = 0.011; 0.50, 0.35-0.70, p < 0.001, respectively]. Additionally, the model (TT + CT vs. CC) of rs2483205 was associated with increased risk of obesity, and the G allele of rs562556 was associated with lower low-density lipoprotein cholesterol (LDL-C), blood glucose, body mass index (BMI), and mean platelet volume (MPV) (all p < 0.05). rs2483205, rs562556, and their H4 haplotype of the PCSK9 gene were associated with CAD. Additionally, rs2483205 is associated with obesity, and rs562556 is associated with LDL-C, blood glucose, BMI, and MPV.

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