Evaluation of Microwave-Assisted Extraction Method for Preparation and Assessment of Thai Herbal Medicine Oral Tablets With Enriched Phytochemical Compounds.

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Abstrakt

Tytuł:: Evaluation of Microwave-Assisted Extraction Method for Preparation and Assessment of Thai Herbal Medicine Oral Tablets With Enriched Phytochemical Compounds.
Autorzy:: Jaisamut P; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand. .; Traditional Thai Medical Research and Innovation Center, Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand. .
Wanna S; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Thanakoon A; Department of Thai Traditional Medicine, Bantakhun Hospital, Bantakhun, Surat Thani, 84230, Thailand.
Saejew S; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Saowapark N; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Suchato W; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Chumvong P; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Kosawiwat T; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Momaklua P; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Chusri S; School of Health Science, Mae Fah Luang University, Muang, Chiang Rai, 57100, Thailand.
Źródło:: AAPS PharmSciTech [AAPS PharmSciTech] 2021 Jun 02; Vol. 22 (5), pp. 167. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: New York : Springer
Original Publication: Arlington, VA : American Association of Pharmaceutical Scientists, c2000-
MeSH Terms:: Microwaves*
Chemistry, Pharmaceutical/*methods
Phytochemicals/*chemical synthesis
Plant Preparations/*chemical synthesis
Administration, Oral ; Antioxidants/administration & dosage ; Antioxidants/chemical synthesis ; Antioxidants/pharmacokinetics ; Drug Evaluation, Preclinical/methods ; Free Radical Scavengers/administration & dosage ; Free Radical Scavengers/chemical synthesis ; Free Radical Scavengers/pharmacokinetics ; Herbal Medicine/methods ; Humans ; Phytochemicals/administration & dosage ; Phytochemicals/pharmacokinetics ; Plant Preparations/administration & dosage ; Plant Preparations/pharmacokinetics ; Tablets ; Thailand
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Contributed Indexing:: Keywords: antioxidant activity; dry granulation; herbal formulation; medicinal plants; microwave-assisted extraction
Substance Nomenclature:: 0 (Antioxidants)
0 (Free Radical Scavengers)
0 (Phytochemicals)
0 (Plant Preparations)
0 (Tablets)
Entry Date(s):: Date Created: 20210603 Date Completed: 20210614 Latest Revision: 20210727
Update Code:: 20221213
DOI:: 10.1208/s12249-021-02052-4
PMID:: 34080078
: Czasopismo naukowe

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In developing countries, populations have employed herbal medicines for primary health care because they are believed to be more appropriate to the human body and have less side effects than chemically synthesized drugs. The present study aimed to develop and evaluate herbal tablets incorporated with a Thai traditional medicinal extract, U-pa-ri-waat (URW), using microwave-assisted extraction (MAE). The extraction efficiency for URW using MAE and traditional solvent extraction was compared based on the percent yield after spray drying. URW tablets were prepared using the dry granulation method. The optimized products were assessed using standard characterization methods based on the United States and British Pharmacopeias. DPPH and ABTS radical scavenging assays were performed to analyze the antioxidant capacity of the microwave-assisted extracts. The results revealed that the flowability of the dry granule with added maltodextrin was improved compared to a granule without additives, as indicated by an angle of repose of 33.69 ± 2.0°, a compressibility index of 15.38 ± 0.66, and a Hausner's ratio of 1.18 ± 0.06. The resulting formulation produced flat tablets with uniform weight variation, hardness, thickness, friability, and optimum disintegration time. The URW extracts showed antioxidant activity and MAE with maltodextrin carrier displayed the strongest DPPH and ABTS radical activities with IC50 values of 1.60 ± 0.02 μg/mL and 4.02 ± 0.24 μg/mL, respectively. The URW tablet formulation passed the quality control tests. Storage of the formulation tablets for 90 days under accelerated conditions had minimal effects on tablet characteristics.

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