Diabetes induces macrophage dysfunction through cytoplasmic dsDNA/AIM2 associated pyroptosis.

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Abstrakt

Tytuł:: Diabetes induces macrophage dysfunction through cytoplasmic dsDNA/AIM2 associated pyroptosis.
Autorzy:: Nie L; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhao P; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yue Z; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhang P; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Ji N; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Chen Q; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Chengdu, China.
Wang Q; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Chengdu, China.
Źródło:: Journal of leukocyte biology [J Leukoc Biol] 2021 Sep; Vol. 110 (3), pp. 497-510. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2023- : Oxford : Oxford University Press
Original Publication: New York : Alan R. Liss, c1984-
MeSH Terms:: Pyroptosis*/drug effects
Cytoplasm/*metabolism
DNA/*metabolism
DNA-Binding Proteins/*metabolism
Diabetes Mellitus, Experimental/*pathology
Macrophages/*pathology
Aging/pathology ; Animals ; Antigen Presentation/drug effects ; Chemotaxis/drug effects ; Cytokines/metabolism ; Glucose/toxicity ; Hyperglycemia/complications ; Inflammation Mediators/metabolism ; Macrophages/drug effects ; Metformin/pharmacology ; Mice ; Mice, Inbred C57BL ; Models, Biological ; Periodontium/pathology ; Phagocytosis/drug effects ; RAW 264.7 Cells
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Contributed Indexing:: Keywords: diabetes mellitus; macrophage; metformin; pyroptosis
Substance Nomenclature:: 0 (Aim2 protein, mouse)
0 (Cytokines)
0 (DNA-Binding Proteins)
0 (Inflammation Mediators)
9007-49-2 (DNA)
9100L32L2N (Metformin)
IY9XDZ35W2 (Glucose)
Entry Date(s):: Date Created: 20210604 Date Completed: 20210910 Latest Revision: 20210910
Update Code:: 20240105
DOI:: 10.1002/JLB.3MA0321-745R
PMID:: 34085308
: Czasopismo naukowe

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Diabetes is emerging as a severe global health problem that threatens health and increases socioeconomic burden. Periodontal impairment is one of its well-recognized complications. The destruction of the periodontal defense barrier makes it easier for periodontal pathogens to invade in, triggering a greater inflammatory response, and causing secondary impairment. Macrophages are the major immune cells in periodontium, forming the frontier line of local innate immune barrier. Here, we explored the periodontal impairments and functional changes of macrophages under the diabetic and aging conditions. Besides, we further explored the molecular mechanism of how hyperglycemia and aging contribute to this pathogenesis. To test this, we used young and aged mice to build diabetic mice, and metformin treatment was applied to a group of them. We demonstrated that under hyperglycemia conditions, macrophage functions, such as inflammatory cytokines secretion, phagocytosis, chemotaxis, and immune response, were disturbed. Simultaneously, this condition elevated the local senescent cell burden and induced secretion of senescence-associated secretory phenotype. Meanwhile, we found that expressions of Gasdermin D (GSDMD) and caspase-1 were up-regulated in diabetic conditions, suggesting that the local senescent burden and systemic proinflammatory state during diabetes were accompanied by the initiation of pyroptosis. Furthermore, we found that the changes in aged condition were similar to those in diabetes, suggesting a hyperglycemia-induced pre-aging state. In addition, we show that metformin treatment alleviated and remarkably reversed these functional abnormalities. Our data demonstrated that diabetes initiated macrophage pyroptosis, which further triggered macrophage function impairments and gingival destructions. This pathogenesis could be reversed by metformin.
(©2021 Society for Leukocyte Biology.)

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