-
Tytuł:
-
Characteristics and outcomes of hospitalised older patients with chronic kidney disease and COVID-19: A multicenter nationwide controlled study.
-
Autorzy:
-
Ozturk S; Department of Internal Medicine, Division of Nephrology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.; Department of Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey.
Turgutalp K; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Education and Research Hospital, Mersin University, Mersin, Turkey.
Arici M; Department of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Gok M; Department of Nephrology, Sultan Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Islam M; Department of Nephrology, Zonguldak Ataturk State Hospital, Zonguldak, Turkey.
Altiparmak MR; Division of Nephrology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Aydin Z; Department of Nephrology, Darica Farabi Training and Research Hospital, Kocaeli, Turkey.
Doner B; Department of Nephrology, Bursa City Hospital, Bursa, Turkey.
Eren N; Department of Nephrology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Sengul E; Division of Nephrology, Kocaeli Derince Education and Research Hospital, Health Science University, Kocaeli, Turkey.
Karadag S; Department of Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey.
Ozler TE; Division of Nephrology, Department of Internal Medicine, Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, Turkey.
Dheir H; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Education and Research Hospital, Sakarya University, Sakarya, Turkey.
Pembegul I; Department of Nephrology, Malatya Turgut Özal University, Malatya, Turkey.
Guven Taymez D; Department of Nephrology and Dialysis, Kocaeli State Hospital, Kocaeli, Turkey.
Sahin G; Department of Internal Medicine, Division of Nephrology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
Bakirdogen S; Division of Nephrology, Department of Internal Medicine, School of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Dolarslan ME; Division of Nephrology, Trabzon Kanuni Education and Research Hospital, University of Health Sciences, Trabzon, Turkey.
Soypacaci Z; Division of Nephrology, Department of İnternal Medicine, Atatürk Education and Research Hospital, Izmir Katip Celebi University, İzmir, Turkey.
Hur E; Merkezefendi State Hospital Nephrology Clinic, Manisa, Turkey.
Kara E; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
Basturk T; Department of Nephrology, Sisli Hamidiye Etfal Education and Research Hospital, Health Sciences University, Istanbul, Turkey.
Ogutmen MB; Department of Nephrology, Haydarpasa Numune Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Gorgulu N; Department of Internal Medicine, Division of Nephrology, University of Health Sciences, Bagcilar Training and Research Hospital, Istanbul, Turkey.
Sahin I; Division of Nephrology, Department of Internal Medicine, Turgut Ozal Medical Center, School of Medicine, Inonu University, Malatya, Turkey.
Ayli MD; Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, University of Health Sciences, Ankara, Turkey.
Tuglular ZS; Department of Internal Medicine, Division of Nephrology, School of Medicine, Marmara University Pendik Education and Research Hospital, Marmara University, Istanbul, Turkey.
Sahin G; Department of Nephrology, Sultan Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Tokgoz B; Department of Nephrology, School of Medicine, Erciyes University, Kayseri, Turkey.
Tonbul HZ; Department of Internal Medicine, Division of Nephrology, Necmettin Erbakan University, Konya, Turkey.
Yildiz A; Department of Internal Medicine, Division of Nephrology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
Sezer S; Department of Internal Medicine and Nephrology, Faculty of Medicine, Atilim University, Ankara, Turkey.
Odabas AR; Department of Nephrology, Sultan Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Ates K; Department of Nephrology, Faculty of Medicine, Ankara University, Ankara, Turkey.
-
Źródło:
-
International journal of clinical practice [Int J Clin Pract] 2021 Sep; Vol. 75 (9), pp. e14428. Date of Electronic Publication: 2021 Jun 17.
-
Typ publikacji:
-
Journal Article; Multicenter Study
-
Język:
-
English
-
Imprint Name(s):
-
Publication: 2022- : Mumbai : Hindawi
Original Publication: Esher [England] ; Bronxville, N.Y. : Medicom International, c1997-
-
MeSH Terms:
-
COVID-19*
Renal Insufficiency, Chronic*/complications
Renal Insufficiency, Chronic*/epidemiology
Renal Insufficiency, Chronic*/therapy
Aged ; COVID-19 Testing ; Female ; Hospitalization ; Humans ; Middle Aged ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
-
References:
-
JAMA Intern Med. 2021 Apr 1;181(4):439-448. (PMID: 33394006)
Kidney Int. 2005 Jun;67(6):2508-19. (PMID: 15882306)
Nephrol Dial Transplant. 2011 Jun;26(6):1862-71. (PMID: 21051501)
Int J Surg. 2014 Dec;12(12):1500-24. (PMID: 25046751)
Kidney360. 2020 Sep 11;1(11):1254-1258. (PMID: 35372874)
Adv Chronic Kidney Dis. 2019 Jan;26(1):8-15. (PMID: 30876622)
MMWR Morb Mortal Wkly Rep. 2020 Mar 27;69(12):343-346. (PMID: 32214079)
JAMA. 2020 Apr 7;323(13):1239-1242. (PMID: 32091533)
J Nutr Health Aging. 2020;24(9):928-937. (PMID: 33155617)
BMC Nephrol. 2021 Jan 14;22(1):29. (PMID: 33446135)
J Am Coll Radiol. 2020 Jun;17(6):701-709. (PMID: 32283052)
Int J Infect Dis. 2021 Jan;102:415-421. (PMID: 33130213)
JAMA. 2020 May 26;323(20):2052-2059. (PMID: 32320003)
Kidney Int. 2020 May;97(5):829-838. (PMID: 32247631)
Kidney Int. 2020 Dec;98(6):1540-1548. (PMID: 32979369)
Int Urol Nephrol. 2020 Jun;52(6):1193-1194. (PMID: 32222883)
Kidney Int. 2020 Dec;98(6):1519-1529. (PMID: 32858081)
J Am Soc Nephrol. 2020 Jul;31(7):1387-1397. (PMID: 32385130)
J Am Soc Nephrol. 2005 Feb;16(2):489-95. (PMID: 15590763)
Nephrol Dial Transplant. 2020 Dec 4;35(12):2083-2095. (PMID: 33275763)
Hypertension. 2020 Aug;76(2):366-372. (PMID: 32564693)
Clin J Am Soc Nephrol. 2020 Aug 7;15(8):1139-1145. (PMID: 32444393)
J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):e68-e75. (PMID: 32871002)
Ann Intern Med. 2009 May 5;150(9):604-12. (PMID: 19414839)
Kidney360. 2020 Jun 18;1(8):755-762. (PMID: 35372963)
Lancet. 2012 Nov 10;380(9854):1649-61. (PMID: 23013600)
Lancet. 2020 Oct 24;396(10259):1335-1344. (PMID: 32987007)
J Infect. 2020 Jun;80(6):639-645. (PMID: 32240670)
Int J Clin Pract. 2021 Sep;75(9):e14428. (PMID: 34085352)
Circulation. 2003 Oct 28;108(17):2154-69. (PMID: 14581387)
-
Entry Date(s):
-
Date Created: 20210604 Date Completed: 20210817 Latest Revision: 20220716
-
Update Code:
-
20240105
-
PubMed Central ID:
-
PMC8236999
-
DOI:
-
10.1111/ijcp.14428
-
PMID:
-
34085352
-
Objective: Older adults with co-morbidities have been reported to be at higher risk for adverse outcomes of coronavirus disease 2019 (COVID-19). The characteristics of COVID-19 in older patients and its clinical outcomes in different kidney disease groups are not well known.
Methods: Data were retrieved from a national multicentric database supported by Turkish Society of Nephrology, which consists of retrospectively collected data between 17 April 2020 and 31 December 2020. Hospitalised patients aged 18 years or older with confirmed COVID-19 diagnosis suffering from stage 3-5 chronic kidney disease (CKD) or on maintenance haemodialysis (HD) treatment were included in the database. Non-uraemic hospitalised patients with COVID-19 were also included as the control group.
Results: We included 879 patients [388 (44.1%) female, median age: 63 (IQR: 50-73) years]. The percentage of older patients in the CKD group was 68.8% (n = 188/273), in the HD group was 49.0% (n = 150/306) and in the control group was 30.4% (n = 70/300). Co-morbidities were higher in the CKD and HD groups. The rate of presentation with severe-critical disease was higher in the older CKD and HD groups (43.6%, 55.3% and 16.1%, respectively). Among older patients, the intensive care unit (ICU) admission rate was significantly higher in the CKD and HD groups than in the control group (38.8%, 37.3% and 15.7%, respectively). In-hospital mortality or death and/or ICU admission rates in the older group were significantly higher in the CKD (29.3% and 39.4%) and HD groups (26.7% and 30.1%) compared with the control group (8.6% and 17.1%). In the multivariate analysis, in-hospital mortality rates in CKD and HD groups were higher than control group [hazard ratio (HR): 4.33 (95% confidence interval [CI]: 1.53-12.26) and HR: 3.09 (95% CI: 1.04-9.17), respectively].
Conclusion: Among older COVID-19 patients, in-hospital mortality is significantly higher in those with stage 3-5 CKD and on maintenance HD than older patients without CKD regardless of demographic characteristics, co-morbidities, clinical and laboratory data on admission.
(© 2021 John Wiley & Sons Ltd.)
