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Tytuł:
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Recommendations for Toxicological Investigation of Drug-Impaired Driving and Motor Vehicle Fatalities-2021 Update.
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Autorzy:
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D'Orazio AL; Center for Forensic Science Research and Education, Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA 19090, USA.; NMS Labs, 200 Welsh Road, Horsham, PA 19044, USA.
Mohr ALA; Center for Forensic Science Research and Education, Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA 19090, USA.
Chan-Hosokawa A; NMS Labs, 200 Welsh Road, Horsham, PA 19044, USA.
Harper C; Alabama Department of Forensic Sciences, 2026 Valleydale Road, Hoover, AL 35244, USA.
Huestis MA; Huestis and Smith Toxicology, LLC, 683 Shore Road, Severna Park, MD 21146, USA.
Limoges JF; New York State Police Forensic Investigation Center, 1220 Washington Avenue, Building 30, Albany, NY 12226-3000, USA.
Miles AK; Wisconsin State Laboratory of Hygiene, 2601 Agriculture Drive, PO Box 7996, Madison, WI 53707-7996, USA.
Scarneo CE; New England Forensic Toxicology, LLC, PO Box 702, Concord, NH 03302, USA.
Kerrigan S; Sam Houston State University, 1003 Bowers Boulevard, Huntsville, TX 77341, USA.
Liddicoat LJ; Center for Forensic Science Research and Education, Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA 19090, USA.
Scott KS; Arcadia University, 450 S Easton Road, Glenside, PA 19038, USA.
Logan BK; Center for Forensic Science Research and Education, Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA 19090, USA.; NMS Labs, 200 Welsh Road, Horsham, PA 19044, USA.
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Źródło:
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Journal of analytical toxicology [J Anal Toxicol] 2021 Jul 10; Vol. 45 (6), pp. 529-536.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2012- : Oxford : Oxford University Press
Original Publication: 1977-<2011>: Niles, Ill., Preston Publications.
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MeSH Terms:
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Automobile Driving*
Driving Under the Influence*
Pharmaceutical Preparations*
Substance-Related Disorders*
Accidents, Traffic ; Canada ; Humans ; Motor Vehicles ; Substance Abuse Detection
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References:
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Forensic Sci Int. 2005 Jun 10;150(2-3):165-73. (PMID: 15899565)
Clin Biochem Rev. 2006 Aug;27(3):147-59. (PMID: 17268583)
J Forensic Sci. 2007 Sep;52(5):1214-8. (PMID: 17680796)
J Anal Toxicol. 2019 Jul 24;43(6):415-443. (PMID: 31263897)
J Anal Toxicol. 2013 Oct;37(8):552-8. (PMID: 23943437)
J Anal Toxicol. 2017 Sep 1;41(7):573-610. (PMID: 28459969)
Traffic Inj Prev. 2014;15(2):111-8. (PMID: 24345011)
J Anal Toxicol. 2016 Mar;40(2):89-96. (PMID: 26687103)
Clin Chem. 2009 Nov;55(11):1910-31. (PMID: 19745062)
J Anal Toxicol. 2019 Apr 1;43(3):228-232. (PMID: 30295809)
J Anal Toxicol. 2018 Mar 1;42(2):63-68. (PMID: 29186455)
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Grant Information:
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Fredric Rieders Family Foundation
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Substance Nomenclature:
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0 (Pharmaceutical Preparations)
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Entry Date(s):
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Date Created: 20210604 Date Completed: 20210713 Latest Revision: 20220531
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Update Code:
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20240105
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PubMed Central ID:
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PMC8272528
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DOI:
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10.1093/jat/bkab064
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PMID:
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34086916
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This report describes updates to the National Safety Council's Alcohol, Drugs and Impairment Division's recommendations for drug testing in driving under the influence of drug (DUID) cases and motor vehicle fatalities. The updates are based on a survey of drug testing practices in laboratories in the USA and Canada, a comprehensive review of the prior recommendations and data and research on drugs most frequently detected in DUID cases. A consensus meeting was held with representative forensic science practitioners and the authors of this report to update recommendations. No changes were made to the Tier I scope; however, there were changes to cutoffs of some analytes for blood, urine and oral fluid. Due to increased prevalence in DUID cases, trazodone and difluoroethane were added to the Tier II scope. For clarification, Tier I cutoffs reflect free concentrations, and hydrolysis is recommended but not required. The consensus panel concluded that urine is an inferior matrix to blood and oral fluid as it may represent historical use or exposure unrelated to observed impairment; therefore, future iterations of these recommendations will not include urine as a recommended matrix. Laboratories currently testing urine should work with traffic safety partners to encourage the use of blood and oral fluid as more appropriate specimens and adjust their capabilities to provide that testing.
(© The Author(s) 2021. Published by Oxford University Press.)
