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Tytuł:
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Clinicopathological findings of systemic Epstein-Barr virus-positive T-lymphoproliferative diseases in younger and older adults.
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Autorzy:
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Wang Z; Graduate School of Medical Sciences, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 8140180, Japan.; Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 8140180, Japan.
Kimura S; Graduate School of Medical Sciences, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 8140180, Japan.; Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 8140180, Japan.
Iwasaki H; Departments of Hematology, Clinical Research Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 8108563, Japan.
Takase K; Departments of Hematology, Clinical Research Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 8108563, Japan.
Oshiro Y; Department of Pathology, Matsuyama Red Cross Hospital, 1 Bunkyo-cho, Matsuyama, 7910000, Japan.
Gamachi A; Department of Pathology, Almeida Memorial Hospital, 1509-2. Oita, Miyazaki, 8701195, Japan.
Makihara K; Department of Pathology, Kyushu Rosai Hospital, 1-1, Sonekita, Kokura South Ward, Kitakyushu, 800-0296, Japan.
Ogata M; Departments of Hematology, Faculty of Medicine, Oita University, Idaigaoka, Hazama-machi, Yufushi, Oita, 8795593, Japan.
Daa T; Departments of Pathology, Faculty of Medicine, Oita University, Idaigaoka, Hazama-machi, Yufushi, Oita, 8795593, Japan.
Momosaki S; Departments of Pathology, Clinical Research Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 8108563, Japan.
Takamatsu Y; Departments of Internal Medicine, Division of Medical Oncology, Hematology and Infectious Disease, Faculty of Medicine, and Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 8140180, Japan.
Takeshita M; Graduate School of Medical Sciences, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 8140180, Japan. .; Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 8140180, Japan. .
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Źródło:
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Diagnostic pathology [Diagn Pathol] 2021 Jun 04; Vol. 16 (1), pp. 48. Date of Electronic Publication: 2021 Jun 04.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: [London] : BioMed Central, 2006-
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MeSH Terms:
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Cell Proliferation*
CD8-Positive T-Lymphocytes/*pathology
Epstein-Barr Virus Infections/*pathology
Herpesvirus 4, Human/*pathogenicity
Lymphohistiocytosis, Hemophagocytic/*pathology
Lymphoma, T-Cell/*pathology
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/analysis ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/virology ; Cell Transformation, Viral ; Child, Preschool ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/therapy ; Epstein-Barr Virus Infections/virology ; Female ; Host-Pathogen Interactions ; Humans ; Lymphohistiocytosis, Hemophagocytic/immunology ; Lymphohistiocytosis, Hemophagocytic/therapy ; Lymphohistiocytosis, Hemophagocytic/virology ; Lymphoma, T-Cell/immunology ; Lymphoma, T-Cell/therapy ; Lymphoma, T-Cell/virology ; Male ; Middle Aged ; Remission Induction ; Retrospective Studies ; Stem Cell Transplantation ; Treatment Outcome ; Young Adult
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References:
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Grant Information:
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No. 17K08732) Grant-in-Aid for Scientific Research (No. 17K08732) from the Ministry of Education, Science and Culture of Japan
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Contributed Indexing:
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Keywords: CD8+ T-cell lymphoma; Epstein-Barr virus; Hemophagocytic lymphohistiocytosis; Systemic EBV+ T-cell lymphoma of childhood
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Substance Nomenclature:
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0 (Antineoplastic Agents)
0 (Biomarkers, Tumor)
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Entry Date(s):
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Date Created: 20210605 Date Completed: 20211213 Latest Revision: 20211214
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Update Code:
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20240105
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PubMed Central ID:
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PMC8176609
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DOI:
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10.1186/s13000-021-01107-1
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PMID:
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34088321
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Background: Systemic Epstein-Barr virus + T-cell lymphoma (sEBV + TCL) occurs in childhood and young adults, and is exceptionally rare in older adults.
Methods: We investigated clinicopathological features in 16 patients of various ages with systemic EBV + CD8 + T-lymphoproliferative diseases.
Results: Eight younger patients and four of eight older adults had sEBV + CD8 + TCL, with invasion by medium-sized to/or large atypical lymphocytes primarily in bone marrow and lymph nodes, hemophagocytic lymphohistiocytosis (HLH), and progressive clinicopathological course. A further two patients demonstrated EBV + node-based CD8 + large TCL without HLH, while the remaining two had the systemic form of chronic active EBV infection (sCAEBV) with CD8 + small lymphocytes. Past history of sCAEBV-like lesions was observed in one sEBV + TCL patient (8.3%). Immunohistologically, in 12 sEBV + TCL patients, atypical lymphocytes were positive for phosphate signal transducer and activator of transcription 3 (66.7%), CMYC (83.3%), and p53 (75%). Strong reactions of programmed cell death-ligand (PD-L)1 + tumor or non-neoplastic cells were detected in nine sEBV + TCL patients (75%). Clonal peaks of the T-cell receptor (TCR) γ gene were detected in eight sEBV + TCL patients by polymerase chain reaction. Four younger patients in sEBV + TCL (33.3%) are in remission with chemotherapies including etoposide, and three of the four underwent allogeneic stem cell transplantation (SCT).
Conclusion: sEBV + CD8 + TCL was observed in younger and older adults with less history of sCAEBV. HLH, tumor cell atypia, immunohistological findings, and progressive clinical course were characteristic of sEBV + CD8 + TCL. Prompt chemotherapy and SCT induced tumor regression in sEBV + CD8 + TCL patients.