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Tytuł:
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A decade of drug-resistant tuberculous meningitis: A wake-up call for patient-centric therapy.
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Autorzy:
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Sharma K; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address: .
Sharma M; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Department of Microbiology, AIIMS, Bilaspur, Himachal Pradesh, India.
Modi M; Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Goyal M; Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Sharma A; Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ray P; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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Źródło:
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Indian journal of medical microbiology [Indian J Med Microbiol] 2021 Jul; Vol. 39 (3), pp. 370-372. Date of Electronic Publication: 2021 Jun 02.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2021- : [New York] : Elsevier
Original Publication: New Delhi : Indian Association of Medical Microbiologists
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MeSH Terms:
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Antitubercular Agents*/pharmacology
Antitubercular Agents*/therapeutic use
Tuberculosis, Meningeal*/drug therapy
Tuberculosis, Multidrug-Resistant/*drug therapy
Fluoroquinolones/pharmacology ; Humans ; Isoniazid/pharmacology ; Mycobacterium tuberculosis ; Patient-Centered Care ; Rifampin/pharmacology
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Contributed Indexing:
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Keywords: Drug resistant tuberculosis; Heteroresistance; MTBDRplus
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Substance Nomenclature:
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0 (Antitubercular Agents)
0 (Fluoroquinolones)
V83O1VOZ8L (Isoniazid)
VJT6J7R4TR (Rifampin)
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Entry Date(s):
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Date Created: 20210606 Date Completed: 20211229 Latest Revision: 20211229
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Update Code:
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20240105
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DOI:
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10.1016/j.ijmmb.2021.05.013
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PMID:
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34090744
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On analyzing the drug susceptibility profile of 151 clinical isolates collected from patients of tuberculous meningitis (TBM) over 10 years, we reflect on few lessons learnt from the trend of susceptibility profile - drug resistance was not uncommon, fluoroquinolone resistance was observed even among otherwise susceptible isolates and hetero-resistance was observed against rifampicin, isoniazid and also fluoroquinolones. In the midst of widening gap between incidence of drug resistant TBM and availability of effective drugs, our data suggests that universal testing for drug resistance, careful choice of drugs having optimal penetration and individualized therapy should form important pillars of TBM management.
Competing Interests: Declaration of competing interest None.
(Copyright © 2021 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights reserved.)
