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Tytuł pozycji:

Heterotrimeric Kinesin II is required for flagellar assembly and elongation of nuclear morphology during spermiogenesis in Schmidtea mediterranea.

Tytuł:
Heterotrimeric Kinesin II is required for flagellar assembly and elongation of nuclear morphology during spermiogenesis in Schmidtea mediterranea.
Autorzy:
Christman DA; Department of Biological Sciences, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH, 45435-0001, USA.
Curry HN; Department of Biological Sciences, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH, 45435-0001, USA.
Rouhana L; Department of Biological Sciences, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH, 45435-0001, USA. Electronic address: .
Źródło:
Developmental biology [Dev Biol] 2021 Sep; Vol. 477, pp. 191-204. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: San Diego, CA : Elsevier
Original Publication: New York.
MeSH Terms:
Kinesins/*physiology
Planarians/*cytology
Sperm Tail/*physiology
Spermatogenesis/*physiology
Animals ; Cell Nucleus/ultrastructure ; Cytoskeletal Proteins/physiology ; Gene Knockdown Techniques ; Kinesins/chemistry ; Kinesins/genetics ; Male ; RNA Interference ; Sperm Head/ultrastructure ; Sperm Tail/ultrastructure
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Grant Information:
R15 HD082754 United States HD NICHD NIH HHS
Contributed Indexing:
Keywords: Cilia; Flagella; Heterotrimeric kinesin II; Manchette; Planarian; Spermatogenesis; Spermiogenesis
Substance Nomenclature:
0 (Cytoskeletal Proteins)
147096-75-1 (kinesin-II)
EC 3.6.4.4 (Kinesins)
Entry Date(s):
Date Created: 20210606 Date Completed: 20211013 Latest Revision: 20220902
Update Code:
20240105
PubMed Central ID:
PMC8277772
DOI:
10.1016/j.ydbio.2021.05.018
PMID:
34090925
Czasopismo naukowe
Development of sperm requires microtubule-based movements that drive assembly of a compact head and flagellated tails. Much is known about how flagella are built given their shared molecular core with motile cilia, but less is known about the mechanisms that shape the sperm head. The Kinesin Superfamily Protein 3A (KIF3A) pairs off with a second motor protein (KIF3B) and the Kinesin Associated Protein 3 (KAP3) to form Heterotrimeric Kinesin II. This complex drives intraflagellar transport (IFT) along microtubules during ciliary assembly. We show that KIF3A and KAP3 orthologs in Schmidtea mediterranea are required for axonemal assembly and nuclear elongation during spermiogenesis. Expression of Smed-KAP3 is enriched during planarian spermatogenesis with transcript abundance peaking in spermatocyte and spermatid cells. Disruption of Smed-kif3A or Smed-KAP3 expression by RNA-interference results in loss of spermatozoa and accumulation of unelongated spermatids. Confocal microscopy of planarian testis lobes stained with alpha-tubulin antibodies revealed that spermatids with disrupted Kinesin II function fail to assemble flagella, and visualization with 4',6-diamidino-2-phenylindole (DAPI) revealed reduced nuclear elongation. Disruption of Smed-kif3A or Smed-KAP3 expression also resulted in edema, reduced locomotion, and loss of epidermal cilia, which corroborates with somatic phenotypes previously reported for Smed-kif3B. These findings demonstrate that heterotrimeric Kinesin II drives assembly of cilia and flagella, as well as rearrangements of nuclear morphology in developing sperm. Prolonged activity of heterotrimeric Kinesin II in manchette-like structures with extended presence during spermiogenesis is hypothesized to result in the exaggerated nuclear elongation observed in sperm of turbellarians and other lophotrochozoans.
(Copyright © 2021 Elsevier Inc. All rights reserved.)

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