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Tytuł:
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A bi-layered membrane with micro-nano bioactive glass for guided bone regeneration.
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Autorzy:
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Li P; Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510000, PR China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510000, PR China.
Li Y; Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510000, PR China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510000, PR China.
Kwok T; Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510000, PR China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510000, PR China.
Yang T; Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510000, PR China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510000, PR China.
Liu C; Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, 510006, PR China.
Li W; Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510000, PR China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510000, PR China. Electronic address: .
Zhang X; Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510000, PR China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510000, PR China. Electronic address: .
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Źródło:
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Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2021 Sep; Vol. 205, pp. 111886. Date of Electronic Publication: 2021 May 30.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam ; New York : Elsevier, c1993-
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MeSH Terms:
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Biocompatible Materials*/pharmacology
Guided Tissue Regeneration*
Bone Regeneration ; Glass ; Membranes, Artificial ; Osteogenesis ; Porosity
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Contributed Indexing:
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Keywords: Barrier membrane; Bi-layered structure; Guided bone regeneration; Micro-Nano bioactive glass
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Substance Nomenclature:
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0 (Biocompatible Materials)
0 (Membranes, Artificial)
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Entry Date(s):
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Date Created: 20210606 Date Completed: 20210720 Latest Revision: 20210720
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Update Code:
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20240105
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DOI:
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10.1016/j.colsurfb.2021.111886
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PMID:
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34091371
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Guided bone regeneration (GBR) is widely used to treat oral bone defects. However, the osteogenic effects are limited by the deficiency of the available barrier membranes. In this study, a novel bi-layer membrane was prepared by solvent casting and electrospinning. The barrier layer made of poly (lactic-co-glycolic acid) (PLGA) was smooth and compact, whereas the osteogenic layer consisting of micro-nano bioactive glass (MNBG) and PLGA was rough and porous. The mineralization evaluation confirmed that apatite formed on the membranes in simulated body fluid. Immersion in phosphate-buffered saline led to the degradation of the membranes with proper pH changes. Mechanical tests showed that the bi-layered membranes have stable mechanical properties under dry and wet conditions. The bi-layered membranes have good histocompatibility, and the MNBG/PLGA layer can enhance bone regeneration activity. This was confirmed by cell culture results, expression of osteogenic genes, and immunofluorescence staining of RUNX-related transcription factor 2 and osteopontin. Therefore, the bi-layered membranes could be a promising clinical strategy for GBR surgery.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
