Molecular docking and toxicity assessment of spirodiclofen: protective role of lycopene.

Szczegóły
Abstrakt

Tytuł:: Molecular docking and toxicity assessment of spirodiclofen: protective role of lycopene.
Autorzy:: Çavuşoğlu D; Atabey Vocational School, Department of Plant and Animal Production, Isparta University of Applied Sciences, Isparta, Turkey.
Yalçin E; Faculty of Science and Art, Department of Biology, Giresun University, 28200, Giresun, Turkey.
Çavuşoğlu K; Faculty of Science and Art, Department of Biology, Giresun University, 28200, Giresun, Turkey. .
Acar A; Vocational School of Health Services, Department of Medical Services and Techniques, Giresun University, Giresun, Turkey.
Yapar K; Faculty of Medicine, Department of Pharmacology, Giresun University, Giresun, Turkey.
Źródło:: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Oct; Vol. 28 (40), pp. 57372-57385. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: <2013->: Berlin : Springer
Original Publication: Landsberg, Germany : Ecomed
MeSH Terms:: Onions*
Plant Roots*
4-Butyrolactone/analogs & derivatives ; Lycopene ; Malondialdehyde ; Molecular Docking Simulation ; Spiro Compounds
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Contributed Indexing:: Keywords: Antioxidant enzymes; Comet assay; Genotoxicity; Lipid peroxidation; Lycopene; Molecular docking; Spirodiclofen
Substance Nomenclature:: 0 (Spiro Compounds)
3X7G31F5MX (spirodiclofen)
4Y8F71G49Q (Malondialdehyde)
OL659KIY4X (4-Butyrolactone)
SB0N2N0WV6 (Lycopene)
Entry Date(s):: Date Created: 20210606 Date Completed: 20211012 Latest Revision: 20211012
Update Code:: 20240105
DOI:: 10.1007/s11356-021-14748-y
PMID:: 34091852
: Czasopismo naukowe

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In this study, toxic effects of spirodiclofen and protective role of lycopene against toxic effects were investigated by using physiological, cytogenetic, anatomical, and biochemical parameters. Allium cepa L. bulbs were used as test material. The bulbs were divided into six groups as one control and five application groups. Bulb in the control group was germinated with tap water, and in treatment groups, 20-mg L -1 dose of spirodiclofen 215- and 430-mg L -1 doses of lycopene were applied. Spirodiclofen application caused a decrease in physiological parameters such as germination percentage, root length, and weight increase. Spirodiclofen administration caused a decrease in the percentage of mitotic index (MI) and an increase in DNA fragmentation, micronucleus (MN), and chromosomal aberration (CA) frequency. Spirodiclofen application caused an increase in the level of the oxidant compound malondialdehyde (MDA), changes in the level of antioxidant enzymes, and disruption of the oxidant/antioxidant balance in the cell. Molecular interactions between spirodiclofen and antioxidant enzymes were determined by molecular docking analysis. In addition to physiological, biochemical, and genetic abnormalities, spirodiclofen also caused deformations in the anatomy of the A. cepa root tip meristematic cells. Lycopene treatment showed a protective effect by suppressing the toxic effects of spirodiclofen, causing a significant improvement in the values of selected physiological, cytogenetic, anatomical, and biochemical parameters. As a result, spirodiclofen insecticide caused toxic effects on various parameters in A. cepa, which is a eukaryotic model organism. In order to elucidate the toxicity mechanism, each parameter is associated with each other. Molecular docking method has revealed the effects of spirodiclofen on antioxidant enzymes. Lycopene application together with spirodiclofen resulted in the regression of all toxic effects and improvement in the root tissue. This result shows that lycopene has a strong protective property against spirodiclofen toxicity.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

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