-
Tytuł:
-
Breast Cancer Targeting of a Drug Delivery System through Postsynthetic Modification of Curcumin@N 3 -bio-MOF-100 via Click Chemistry.
-
Autorzy:
-
Alves RC; Department of Drugs and Medicines, School of Pharmaceutical Sciences of São Paulo State University (UNESP), Rodovia Araraquara Jaú, Km 01 - s/n - Campos Ville, 14800-903 Araraquara, São Paulo, Brazil.
Schulte ZM; Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 1560, United States.
Luiz MT; Department of Pharmaceutical Sciences, School of Pharmaceutical Science of Ribeirão Preto, University of São Paulo (USP), Avenida do Café, s/n - Campus da USP, 14040-903 Ribeirão Preto, Sao Paulo, Brazil.
Bento da Silva P; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia (UnB), Campus Universitario Darcy Ribeiro - Asa Norte, 70910-900 Brasilia, Federal District, Brazil.
Frem RCG; Institute of Chemistry, São Paulo State University (UNESP), Prof. Francisco Degni 55, PO Box 355, 14800-970 Araraquara, São Paulo, Brazil.
Rosi NL; Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 1560, United States.
Chorilli M; Department of Drugs and Medicines, School of Pharmaceutical Sciences of São Paulo State University (UNESP), Rodovia Araraquara Jaú, Km 01 - s/n - Campos Ville, 14800-903 Araraquara, São Paulo, Brazil.
-
Źródło:
-
Inorganic chemistry [Inorg Chem] 2021 Aug 16; Vol. 60 (16), pp. 11739-11744. Date of Electronic Publication: 2021 Jun 08.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: [Easton, Pa.] American Chemical Society.
-
MeSH Terms:
-
Molecular Targeted Therapy*
Breast Neoplasms/*drug therapy
Curcumin/*chemistry
Drug Carriers/*chemistry
Metal-Organic Frameworks/*chemistry
Click Chemistry ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Folic Acid/chemistry
-
Substance Nomenclature:
-
0 (Drug Carriers)
0 (Metal-Organic Frameworks)
935E97BOY8 (Folic Acid)
IT942ZTH98 (Curcumin)
-
Entry Date(s):
-
Date Created: 20210608 Date Completed: 20210819 Latest Revision: 20210819
-
Update Code:
-
20240104
-
DOI:
-
10.1021/acs.inorgchem.1c00538
-
PMID:
-
34101467
-
Metal-organic frameworks (MOFs) offer many opportunities for applications across biology and medicine. Their wide range of chemical composition makes toxicologically acceptable formulation possible, and their high level of functionality enables possible applications as delivery systems for therapeutics agents. Surface modifications have been used in drug delivery systems to minimize their interaction with the bulk, improving their specificity as targeted carriers. Herein, we discuss a strategy to achieve a tumor-targeting drug-loaded MOF using "click" chemistry to anchor functional folic acid (FA) molecules on the surface of N 3 -bio-MOF-100. Using curcumin (CCM) as an anticancer drug, we observed drug loading encapsulation efficiencies (DLEs) of 24.02 and 25.64% after soaking N 3 -bio-MOF-100 in CCM solutions for 1 day and 3 days, respectively. The success of postsynthetic modification of FA was confirmed by 1 H NMR spectroscopy, Fourier transform infrared spectroscopy (FTIR), and liquid chromatography-mass spectrometry (LC-MS). The stimuli-responsive drug release studies demonstrated an increase of CCM released under acidic microenvironments. Moreover, the cell viability assay was performed on the 4T1 (breast cancer) cell line in the presence of CCM@N 3 -bio-MOF-100 and CCM@N 3 -bio-MOF-100/FA carriers to confirm its biological compatibility. In addition, a cellular uptake study was conducted to evaluate the targeting of tumor cells.
