Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.

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Abstrakt

Tytuł:: Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.
Autorzy:: Xu H; Yangzhou University Medical College, Yangzhou, Jiangsu, P.R. China.
Xiong C; Dalian Medical University, Dalian, Liaoning, P.R. China.
Chen Y; Yangzhou University Medical College, Yangzhou, Jiangsu, P.R. China.
Zhang C; Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, P.R. China.
Bai D; Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, P.R. China.
Źródło:: Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 2664-2675.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Austin : Landes Bioscience
MeSH Terms:: Carcinoma, Hepatocellular*/diagnosis
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/mortality
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/diagnosis
Liver Neoplasms*/genetics
Liver Neoplasms*/mortality
Liver Neoplasms*/pathology
Neoplasm Invasiveness*/genetics
Neoplasm Invasiveness*/pathology
Rad51 Recombinase/*genetics
Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; DNA Repair/genetics ; Databases, Genetic ; Female ; Humans ; Liver/metabolism ; Liver/pathology ; Male ; Prognosis ; Rad51 Recombinase/metabolism
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Contributed Indexing:: Keywords: DNA repair gene; Hepatocellular carcinoma; ICGC; TCGA; immune infiltration
Substance Nomenclature:: 0 (Biomarkers, Tumor)
EC 2.7.7.- (RAD51 protein, human)
EC 2.7.7.- (Rad51 Recombinase)
Entry Date(s):: Date Created: 20210611 Date Completed: 20211203 Latest Revision: 20230917
Update Code:: 20240104
PubMed Central ID:: PMC8806544
DOI:: 10.1080/21655979.2021.1938470
PMID:: 34115569
: Czasopismo naukowe

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Rad51, a DNA-repair-related gene, has been reported to be involved in multiple cancers. However, its link with immune infiltration in liver cancer still unknown. Therefore, more research into the roles and activities of Rad51 in hepatocellular carcinoma (HCC) is required. The International Cancer Genome Consortium (ICGC) was used to identify the DNA repair gene Rad51, and has been proved to be overexpressed in HCC patients. We plotted the Kapan-Meier curve, demonstrating that patients with high expression of Rad51 have a poor prognosis. By analyzing the patient data, we discovered that high expression of Rad51 in HCC is linked to clinical stage, pathological T stage, grade, and age. Rad51 was found to be an independent prognostic factor for HCC patients using the multivariate cox model. Moreover, Rad51 expression was found to be associated with the infiltration of immune cells (B cells, CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells) and was intimately linked to the expression of immune cell markers in HCC. Through the analysis of differentially coexpressed genes (DCGs) of Rad51, GO and KEGG enrichment analyses suggested that the expression level of Rad51 might be relevant to neuroactive ligand-receptor interactions, the cell cycle, DNA replication, homologous recombination, oocyte meiosis, and the Fanconi anemia pathway. These findings indicated that Rad51 is a valuable biomarker for the prognosis of patients with liver cancer and that its expression has a significant correlation with immune infiltrations. Abbreviations: HCC: hepatocellular carcinoma; ICGC: International Cancer Genome Consortium TCGA: The Cancer Genome Atlas; TIMER: Tumor Immune Estimation Resource; CAF: Cancer-associated fibroblast; GEPIA: Gene Expression Profiling Interactive Analysis; GSEA: Gene set enrichment analysis; OS: overall survival; PFS: progression-free survival; RFS: relapse-free survival; DSS: disease-specific survival. Partial cor: partial correlation coefficient; HPA: Human Protein Atlas; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; CAF: Cancer-associated fibroblast; DCGs: differentially co-expressed genes.

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