Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways. - OpacWWW

Tytuł:: Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways.
Autorzy:: Tan S; PLA Strategic Support Force Characteristic Medical Center, Beijing, People's Republic of China.
Wang H; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China. .
Xu X; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Zhao L; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Zhang J; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Dong J; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Yao B; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Wang H; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Hao Y; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Zhou H; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Gao Y; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Peng R; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China. .
Źródło:: Scientific reports [Sci Rep] 2021 Jun 11; Vol. 11 (1), pp. 12348. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Spatial Memory*
Cyclic AMP Response Element-Binding Protein/*metabolism
Hippocampus/*radiation effects
Microwaves/*adverse effects
Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Delta Rhythm ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Hippocampus/metabolism ; Hippocampus/physiology ; Male ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; Theta Rhythm
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Substance Nomenclature:: 0 (Creb1 protein, rat)
0 (Cyclic AMP Response Element-Binding Protein)
EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
Entry Date(s):: Date Created: 20210612 Date Completed: 20211020 Latest Revision: 20231213
Update Code:: 20240104
PubMed Central ID:: PMC8196025
DOI:: 10.1038/s41598-021-91622-4
PMID:: 34117282
: Czasopismo naukowe

Pełny tekst

This study aimed to evaluate the acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory and cAMP response element binding (CREB)-related pathways. A total of 120 male Wistar rats were divided into four groups: a control group (C); 2.856 GHz microwave exposure group (S group); 1.5 GHz microwave exposure group (L group); and 2.856 and 1.5 GHz cumulative exposure group (SL group). Decreases in spatial memory abilities, changes in EEG, structural injuries, and the downregulation of phosphorylated-Ak strain transforming (p-AKT), phosphorylated-calcium/calmodulin-dependent protein kinase II (p-CaMKII), phosphorylated extracellular signal regulated kinase (p-ERK) and p-CREB was observed 6 h after microwave exposure. Significant differences in the expression of p-CaMKII were found between the S and L groups. The power amplitudes of the EEG waves (θ, δ), levels of structural injuries and the expression of p-AKT, p-CaMK II, p-CREB, and p-ERK1/2 were significantly different in the S and L groups compared to the SL group. Interaction effects between the 2.856 and 1.5 GHz microwaves were found in the EEG and p-CREB changes. Our findings indicated that 2.856 GHz and 1.5 GHz microwave exposure induced a decline in spatial memory, which might be related to p-AKT, p-CaMK II, p-CREB and p-ERK1/2.

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Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways.