Granzyme B-Producing B Cells Function as a Feedback Loop for T Helper Cells in Liver Transplant Recipients with Acute Rejection.

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Tytuł:: Granzyme B-Producing B Cells Function as a Feedback Loop for T Helper Cells in Liver Transplant Recipients with Acute Rejection.
Autorzy:: Xu WL; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Wang RL; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Liu Z; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Wu Q; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Li XL; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
He Q; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China. .
Zhu JQ; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China. dr_.
Źródło:: Inflammation [Inflammation] 2021 Dec; Vol. 44 (6), pp. 2270-2278. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers
Original Publication: New York, Plenum Press.
MeSH Terms:: Cell Communication*
Lymphocyte Activation*/drug effects
B-Lymphocytes/*enzymology
Graft Rejection/*enzymology
Granzymes/*metabolism
Liver Transplantation/*adverse effects
T-Lymphocytes, Helper-Inducer/*enzymology
Acute Disease ; Adult ; Aged ; Antigens, CD19/metabolism ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Case-Control Studies ; Cell Proliferation ; Cells, Cultured ; Coculture Techniques ; Female ; Glucocorticoids/therapeutic use ; Graft Rejection/diagnosis ; Graft Rejection/drug therapy ; Graft Rejection/immunology ; Humans ; Immunosuppressive Agents/therapeutic use ; Interleukin-2 Receptor alpha Subunit/metabolism ; Male ; Middle Aged ; T-Lymphocytes, Helper-Inducer/drug effects ; T-Lymphocytes, Helper-Inducer/immunology ; Up-Regulation
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Grant Information:: 2017YZNS01 Open Project of Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation; 81601392 National Natural Science Foundation of China
Contributed Indexing:: Keywords: B cell; acute rejection; granzyme B; liver transplantation
Substance Nomenclature:: 0 (Antigens, CD19)
0 (CD19 molecule, human)
0 (Glucocorticoids)
0 (IL2RA protein, human)
0 (Immunosuppressive Agents)
0 (Interleukin-2 Receptor alpha Subunit)
EC 3.4.21.- (GZMB protein, human)
EC 3.4.21.- (Granzymes)
Entry Date(s):: Date Created: 20210613 Date Completed: 20220317 Latest Revision: 20220317
Update Code:: 20240105
DOI:: 10.1007/s10753-021-01498-9
PMID:: 34120305
: Czasopismo naukowe

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Granzyme B-producing B cells have been reportedly reported to be an important regulatory B cell subset in the pathogenesis of many diseases. However, its role in liver transplant recipients with acute rejection has never been well elucidated. Seventeen liver transplant recipients with acute rejection and 25 controls with stable liver function were enrolled in this study to determine the function of granzyme B-producing B cells via flow cytometry. Liver transplant recipients with acute rejection had higher expression of granzyme B in CD19 + B cells when compared with controls. Following rejection, the granzyme B production was even elevated although comparison failed to reach significance. The percentages of CD27 + granzyme B + CD19 + B cells and CD138 + granzyme B + CD19 + B cells were lower than those of CD27 - granzyme B + CD19 + B cells and CD138 - granzyme B + CD19 + B cells in patients with acute rejection, respectively. While the production of CD27 and CD138 was not different between liver transplant recipients with and without acute rejection but increased expression of the two surface markers was observed following rejection. Furthermore, the frequency of granzyme B + CD19 + B cells correlated with the level of alanine aminotransferase instead of tacrolimus. CD19 + B cells could produce granzyme B when stimulated with IgG + IgM and CpG in the presence of the supernatant of activated CD4 + CD25 - T cells. In return, granzyme B + CD19 + B cells could suppress the proliferation of CD4 + CD25 - T cells in a granzyme B- and contact-dependent manner. The increased expression of granzyme B in CD19 + B cells from liver transplant recipients with acute rejection might function as a feedback loop for the activation of the CD4 + CD25 - T cells.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

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