Determination of bupivacaine tissue concentration in human biopsy samples using high-performance liquid chromatography with mass spectrometry.

Szczegóły
Abstrakt

Tytuł:: Determination of bupivacaine tissue concentration in human biopsy samples using high-performance liquid chromatography with mass spectrometry.
Autorzy:: Istenič S; Core Facility, Helios TBLUS, Domžale, Slovenia.; Institute of Anatomy, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Cvetko E; Institute of Anatomy, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Zabret J; Core Facility, Helios TBLUS, Domžale, Slovenia.
Stopar Pintarič T; Institute of Anatomy, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.; Department of Anaesthesiology and Intensive Therapy, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Umek N; Institute of Anatomy, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Źródło:: Biomedical chromatography : BMC [Biomed Chromatogr] 2021 Nov; Vol. 35 (11), pp. e5198. Date of Electronic Publication: 2021 Jul 04.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 1990- : Chichester : Wiley
Original Publication: London : Heyden & Son, c1986-1990
MeSH Terms:: Bupivacaine/*analysis
Chromatography, High Pressure Liquid/*methods
Mass Spectrometry/*methods
Biopsy ; Bupivacaine/chemistry ; Bupivacaine/isolation & purification ; Humans ; Linear Models ; Muscle, Skeletal/pathology ; Nerve Tissue/pathology ; Reproducibility of Results ; Sensitivity and Specificity
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Grant Information:: Grant No: P3-0043 Slovenian Research Agency; Tertiary funding University Medical Center Ljubljana
Contributed Indexing:: Keywords: HPLC-MS; biopsy sample; bupivacaine; human tissue; lidocaine
Substance Nomenclature:: Y8335394RO (Bupivacaine)
Entry Date(s):: Date Created: 20210614 Date Completed: 20211116 Latest Revision: 20211116
Update Code:: 20240105
DOI:: 10.1002/bmc.5198
PMID:: 34121212
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In the present study, we developed a simple and rapid analytical method for the quantification of bupivacaine hydrochloride in human biopsy samples of adipose, muscle, neural, connective and cartilage tissue using liquid chromatography-mass spectrometry. Anesthetics were extracted from the tissue samples using 0.1% formic acid in acetonitrile for protein denaturation and hexane for removal of lipophilic impurities. Analytes were separated adequately on Phenomenex Luna Omega polar C18 column using a gradient mobile phase 0.1% formic acid in water and 0.1% formic acid in acetonitrile. The lower limits of quantification were ≤ 97 ng g -1 tissue for all studied tissues. Intra-day recoveries were between 48.2% and 82.1% with relative standard deviations (RSDs) between 1.47% and 14.28%, whereas inter-day recoveries were between 52.2% and 77.6% with RSDs between 2.98% and 14.79%. The calibration curve showed a linear fit with R 2 higher than 0.99 in the concentration range from 0.16 to 100 μg g -1 . Lidocaine hydrochloride was tested as internal standard because its recoveries and matrix effects were comparable to bupivacaine hydrochloride. Post-analytical corrections of measured bupivacaine tissue concentrations can accordingly be made based on recovery of lidocaine as internal standard, with recoveries between 51.2% and 86.9% and RSDs between 1.99% and 16.88%. The developed method could be used to study time-dependent spread of bupivacaine locally or to more distant locations across tissue barriers.
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