-
Tytuł:
-
Chitosan/gelatin-tannic acid decorated porous tape suture with multifunctionality for tendon healing.
-
Autorzy:
-
Zhang Q; Key Laboratory of Textile Science and Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology, Donghua University, Shanghai 201620, China.
Qiao Y; Key Laboratory of Textile Science and Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology, Donghua University, Shanghai 201620, China.
Li C; Key Laboratory of Textile Science and Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology, Donghua University, Shanghai 201620, China.
Lin J; Key Laboratory of Textile Science and Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology, Donghua University, Shanghai 201620, China.
Han H; Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Li X; Key Laboratory of Biomedical Materials and Implants, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China.
Mao J; Key Laboratory of Textile Science and Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology, Donghua University, Shanghai 201620, China. Electronic address: .
Wang F; Key Laboratory of Textile Science and Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology, Donghua University, Shanghai 201620, China.
Wang L; Key Laboratory of Textile Science and Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology, Donghua University, Shanghai 201620, China. Electronic address: .
-
Źródło:
-
Carbohydrate polymers [Carbohydr Polym] 2021 Sep 15; Vol. 268, pp. 118246. Date of Electronic Publication: 2021 May 25.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Publication: <1992-> : Barking : Elsevier Applied Science Publishers
Original Publication: London [Eng.] : Applied Science Publishers, c1981-
-
MeSH Terms:
-
Sutures*
Anti-Bacterial Agents/*therapeutic use
Anti-Inflammatory Agents/*therapeutic use
Inflammation/*drug therapy
Tendons/*drug effects
Wound Healing/*drug effects
Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Chitosan/chemistry ; Chitosan/pharmacology ; Chitosan/therapeutic use ; Escherichia coli/drug effects ; Gelatin/chemistry ; Gelatin/pharmacology ; Gelatin/therapeutic use ; Indoles/chemistry ; Indoles/pharmacology ; Indoles/therapeutic use ; Inflammation/pathology ; Male ; Mice ; Microbial Sensitivity Tests ; Polymers/chemistry ; Polymers/pharmacology ; Polymers/therapeutic use ; Porosity ; RAW 264.7 Cells ; Staphylococcus aureus/drug effects ; Swine ; Tannins/chemistry ; Tannins/pharmacology ; Tannins/therapeutic use ; Tendons/pathology ; Tensile Strength
-
Contributed Indexing:
-
Keywords: Anti-inflammatory; Antibacterial; Load transfer; Porous tape suture; Tendon healing
-
Substance Nomenclature:
-
0 (Anti-Bacterial Agents)
0 (Anti-Inflammatory Agents)
0 (Indoles)
0 (Polymers)
0 (Tannins)
0 (polydopamine)
9000-70-8 (Gelatin)
9012-76-4 (Chitosan)
-
Entry Date(s):
-
Date Created: 20210615 Date Completed: 20211018 Latest Revision: 20211018
-
Update Code:
-
20240104
-
DOI:
-
10.1016/j.carbpol.2021.118246
-
PMID:
-
34127225
-
The inferior tendon healing after surgery is inextricably linked to the surgical suture. Poor load transfer along the suture often results in a high tendon re-tear rate. Besides, the severe inflammation and infection induced by sutures even cause a second surgery. Herein, to alleviate the above-mentioned issues, a multifunctional suture was fabricated by decorating chitosan/gelatin-tannic acid (CS/GE-TA) on the porous tape suture. The porous tape suture ensured the required mechanical properties and sufficient space for tissue integration. Compared to the pristine suture, the CS/GE-TA decorated suture (TA100) presented a 332% increase in pull-out force from the tendon, indicating potentially decreased re-tear rates. Meanwhile, TA100 showed superior anti-inflammatory and antibacterial performances. In vivo experiments further proved that TA100 could not only reduce inflammatory action but also facilitate collagen deposition and blood vessel formation. These results indicate that the multifunctional sutures are promising candidates for accelerating tendon healing.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
