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Tytuł pozycji:

Refining the Identity and Role of Kv4 Channels in Mouse Substantia Nigra Dopaminergic Neurons.

Tytuł:
Refining the Identity and Role of Kv4 Channels in Mouse Substantia Nigra Dopaminergic Neurons.
Autorzy:
Haddjeri-Hopkins A; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE.
Tapia M; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE.
Ramirez-Franco J; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE.
Tell F; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE.
Marqueze-Pouey B; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE.
Amalric M; Unité Mixte de Recherche 7291, Aix Marseille University, Centre National de la Recherche Scientifique, Laboratoire de Neurosciences Cognitives, Marseille 13331, France.
Goaillard JM; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE .
Źródło:
ENeuro [eNeuro] 2021 Jul 20; Vol. 8 (4). Date of Electronic Publication: 2021 Jul 20 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: [Washington, DC] : Society for Neuroscience, [2014]-
MeSH Terms:
Dopaminergic Neurons*
Substantia Nigra*
Action Potentials ; Animals ; Mice ; Mice, Transgenic ; Pars Compacta
References:
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Contributed Indexing:
Keywords: biophysics; computational modeling; dopamine; patch clamp; potassium channels; substantia nigra
Entry Date(s):
Date Created: 20210616 Date Completed: 20210813 Latest Revision: 20210827
Update Code:
20240104
PubMed Central ID:
PMC8293280
DOI:
10.1523/ENEURO.0207-21.2021
PMID:
34131060
Czasopismo naukowe
Substantia nigra pars compacta (SNc) dopaminergic (DA) neurons display a peculiar electrical phenotype characterized in vitro by a spontaneous tonic regular activity (pacemaking activity), a broad action potential (AP) and a biphasic postinhibitory response. The transient A-type current (I A ) is known to play a crucial role in this electrical phenotype, and so far, this current was considered to be carried exclusively by Kv4.3 potassium channels. Using Kv4.3-/- transgenic mice, we demonstrate that the constitutive loss of this channel is associated with increased exploratory behavior and impaired motor learning at the behavioral level. Consistently, it is also associated with a lack of compensatory changes in other ion currents at the cellular level. Using antigen retrieval (AR) immunohistochemistry, we then demonstrate that Kv4.2 potassium channels are also expressed in SNc DA neurons, although their contribution to I A appears significant only in a minority of neurons (∼5-10%). Using correlative analysis on recorded electrophysiological parameters and multicompartment modeling, we then demonstrate that, rather than its conductance level, I A gating kinetics (inactivation time constant) appear as the main biophysical property defining postinhibitory rebound delay and pacemaking frequency. Moreover, we show that the hyperpolarization-activated current (I H ) has an opposing and complementary influence on the same firing features.
(Copyright © 2021 Haddjeri-Hopkins et al.)

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