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Tytuł:
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Clinicopathological characteristics and prognosis of 232 patients with poorly differentiated gastric neuroendocrine neoplasms.
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Autorzy:
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Han D; Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing 100029, China.
Li YL; Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing 100029, China.
Zhou ZW; Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China.
Yin F; Department of Gastroenterology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
Chen J; Department of Gastroenterology, The First Affiliated Hospital Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China.
Liu F; Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China.
Shi YF; Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China.
Wang W; Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China.
Zhang Y; Department of Gastroenterology, The First Affiliated Hospital Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China.
Yu XJ; Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Xu JM; Department of Gastrointestinal Oncology, Affiliated Hospital Cancer Center, Academy of Military Medical Sciences, Beijing 100071, China.
Yang RX; Second Department of Internal Medicine, Yunnan Tumor Hospital, Kunming 650118, Yunnan Province, China.
Tian C; Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing 100029, China.
Luo J; Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China.
Tan HY; Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing 100029, China. .
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Źródło:
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World journal of gastroenterology [World J Gastroenterol] 2021 Jun 07; Vol. 27 (21), pp. 2895-2909.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group
Original Publication: Beijing : WJG Press, c1998-
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MeSH Terms:
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Neuroendocrine Tumors*/pathology
Stomach Neoplasms*/epidemiology
Stomach Neoplasms*/pathology
Aged ; China/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Retrospective Studies
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References:
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Contributed Indexing:
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Keywords: Clinicopathological characteristics; Distant metastasis; Poorly differentiated gastric neuroendocrine neoplasms; Prognosis; Tumor diameter
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Entry Date(s):
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Date Created: 20210617 Date Completed: 20210618 Latest Revision: 20210619
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Update Code:
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20240104
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PubMed Central ID:
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PMC8173377
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DOI:
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10.3748/wjg.v27.i21.2895
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PMID:
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34135560
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Background: Poorly differentiated gastric neuroendocrine neoplasms (PDGNENs) include gastric neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma, which are highly malignant and rare tumors, and their incidence has increased over the past few decades. However, the clinicopathological features and outcomes of patients with PDGNENs have not been completely elucidated.
Aim: To investigate the clinicopathological characteristics and prognostic factors of patients with PDGNENs .
Methods: The data from seven centers in China from March 2007 to November 2019 were analyzed retrospectively.
Results: Among the 232 patients with PDGNENs, 191 (82.3%) were male, with an average age of 62.83 ± 9.11 years. One hundred and thirteen (49.34%) of 229 patients had a stage III disease and 86 (37.55%) had stage IV disease. Three (1.58%) of 190 patients had no clinical symptoms, while 187 (98.42%) patients presented clinical symptoms. The tumors were mainly (89.17%) solitary and located in the upper third of the stomach (cardia and fundus of stomach: 115/215, 53.49%). Most lesions were ulcers (157/232, 67.67%), with an average diameter of 4.66 ± 2.77 cm. In terms of tumor invasion, the majority of tumors invaded the serosa (116/198, 58.58%). The median survival time of the 232 patients was 13.50 mo (7, 31 mo), and the overall 1-year, 3-year, and 5-year survival rates were 49%, 19%, and 5%, respectively. According to univariate analysis, tumor number, tumor diameter, gastric invasion status, American Joint Committee on Cancer (AJCC) stage, and distant metastasis status were prognostic factors for patients with PDGNENs. Multivariate analysis showed that tumor number, tumor diameter, AJCC stage, and distant metastasis status were independent prognostic factors for patients with PDGNENs.
Conclusion: The overall prognosis of patients with PDGNENs is poor. The outcomes of patients with a tumor diameter > 5 cm, multiple tumors, and stage IV tumors are worse than those of other patients.
Competing Interests: Conflict-of-interest statement: The authors have no competing interests to declare.
(©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.)
