Effect of genomic X-chromosome regions on Nelore bull fertility.

Szczegóły
Abstrakt

Tytuł:: Effect of genomic X-chromosome regions on Nelore bull fertility.
Autorzy:: Hermisdorff IDC; Escola de Medicina Veterinária E Zootecnia, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.
Diaz IDPS; Escola de Medicina Veterinária E Zootecnia, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.
de Camargo GMF; Escola de Medicina Veterinária E Zootecnia, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.
de Albuquerque LG; Departamento de Zootecnia, Faculdade de Ciências Agrárias E Veterinárias, Universidade Estadual Paulista (Unesp), Jaboticabal, SP, Brazil.
Costa RB; Escola de Medicina Veterinária E Zootecnia, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil. .
Źródło:: Journal of applied genetics [J Appl Genet] 2021 Dec; Vol. 62 (4), pp. 655-659. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2011- : Cheshire, United Kingdom : Springer
Original Publication: Poznań, Poland : Institute of Plant Genetics, Polish Academy of Sciences, 1995-
MeSH Terms:: Genome-Wide Association Study*
Quantitative Trait Loci*
Animals ; Cattle/genetics ; Female ; Fertility/genetics ; Genomics ; Genotype ; Male ; Phenotype ; Polymorphism, Single Nucleotide ; X Chromosome/genetics
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Contributed Indexing:: Keywords: Bos taurus indicus; Nelore cattle; Scrotal circumference; Sexual chromosomes; Sexual precocity
Entry Date(s):: Date Created: 20210619 Date Completed: 20211109 Latest Revision: 20211109
Update Code:: 20240104
DOI:: 10.1007/s13353-021-00645-0
PMID:: 34145524
: Czasopismo naukowe

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Scrotal circumference (SC) is a commonly used trait related to sexual precocity in bulls. Genome-wide association studies have uncovered a lot of genes related to this trait, however, only those present on autosomes. The inclusion of the second biggest chromosome (BTAX) can improve the knowledge of the genetic architecture of this trait. In this study, we performed a weighted, single-step, genome-wide association study using a 777 k BovineHD BeadChip (IllumHD) to analyze the association between SNPs and SC in Brazilian Nelore cattle. Phenotypes from 79,300 males and 3263 genotypes (2017 from females and 1246 from males)-(39,367 SNPs markers located at ChrX) were used. We identified eight regions on chromosome X that displayed important associations with SC. The results showed that together the genomic windows explained 28.52% of the genetic variance for the examined trait. Genes with potential functions in reproduction and fertility regulation were highlighted as candidates for sexual precocity rates in Nelore cattle (AFF2 and PJA1). Moreover, we found 10 genes that had not previously been identified as being associated with sexual precocity traits in cattle. These findings will further advance our understanding of the genetic architecture, considering mainly the presence of the chromosome X, for indicine cattle reproductive traits, being useful in the context of genomic prediction in beef cattle.
(© 2021. Institute of Plant Genetics, Polish Academy of Sciences, Poznan.)

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