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Tytuł pozycji:

COVID-19: Structural Considerations for Virus Pathogenesis, Therapeutic Strategies and Vaccine Design in the Novel SARS-CoV-2 Variants Era.

Tytuł:
COVID-19: Structural Considerations for Virus Pathogenesis, Therapeutic Strategies and Vaccine Design in the Novel SARS-CoV-2 Variants Era.
Autorzy:
Volkan E; Faculty of Pharmacy, Cyprus International University, via Mersin 10, 99258, Nicosia, Northern Cyprus, Turkey. .; Biotechnology Research Center, Cyprus International University, via Mersin 10, 99258, Nicosia, Northern Cyprus, Turkey. .
Źródło:
Molecular biotechnology [Mol Biotechnol] 2021 Oct; Vol. 63 (10), pp. 885-897. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Publication: [Cham] : Springer
Original Publication: Totowa, NJ : Humana Press, c1994-
MeSH Terms:
COVID-19/*prevention & control
COVID-19/*therapy
COVID-19 Vaccines/*immunology
SARS-CoV-2/*immunology
SARS-CoV-2/*pathogenicity
Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/immunology ; Antibodies, Viral/therapeutic use ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Vaccines/therapeutic use ; Drug Design ; Humans ; SARS-CoV-2/genetics ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism
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Contributed Indexing:
Keywords: Antibody; COVID-19; Coronavirus; SARS-CoV-2; Vaccine; Variant
Substance Nomenclature:
0 (Antibodies, Neutralizing)
0 (Antibodies, Viral)
0 (COVID-19 Vaccines)
0 (Spike Glycoprotein, Coronavirus)
0 (spike protein, SARS-CoV-2)
EC 3.4.17.23 (ACE2 protein, human)
EC 3.4.17.23 (Angiotensin-Converting Enzyme 2)
Entry Date(s):
Date Created: 20210619 Date Completed: 20210924 Latest Revision: 20220218
Update Code:
20240104
PubMed Central ID:
PMC8213040
DOI:
10.1007/s12033-021-00353-4
PMID:
34145550
Czasopismo naukowe
COVID-19 pandemic caused by SARS-CoV-2 globally impacted the humanity causing tragic outcomes; costing millions of lives, destroying economies and demolishing public health infrastructures. The emergence of vaccines using various ingenious approaches in less than a year was deemed the light at the end of the tunnel. However, recent emergence of variants of SARS-CoV-2 in several parts of the world revealed that another hurdle is ahead in the fight against COVID-19. This review will highlight how SARS-CoV-2 mutations, creating different virus variants could potentially impact virus pathogenesis as well as different therapy approaches and vaccine design.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

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