A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq.

Szczegóły
Abstrakt

Tytuł:: A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq.
Autorzy:: Shiau F; John F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Ruzycki PA; John F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Clark BS; John F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: .
Źródło:: Developmental biology [Dev Biol] 2021 Oct; Vol. 478, pp. 41-58. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Język:: English
Imprint Name(s):: Publication: San Diego, CA : Elsevier
Original Publication: New York.
MeSH Terms:: RNA-Seq*
Single-Cell Analysis*
Multipotent Stem Cells/*cytology
Retina/*growth & development
Retinal Neurons/*cytology
Animals ; Cell Lineage ; Gene Expression Regulation, Developmental ; Humans ; Multipotent Stem Cells/metabolism ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Neurogenesis ; Retina/cytology ; Retina/embryology ; Retinal Diseases/genetics ; Retinal Diseases/metabolism ; Retinal Diseases/pathology ; Retinal Neurons/metabolism ; Transcriptome
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Grant Information:: R00 EY027844 United States EY NEI NIH HHS
Contributed Indexing:: Keywords: Cell fate specification; Competence; Neurogenesis; Retinal development; Retinal progenitor cells; Review; Single-cell; Single-cell rna-sequencing; scRNA-seq
Entry Date(s):: Date Created: 20210619 Date Completed: 20211015 Latest Revision: 20240403
Update Code:: 20240403
PubMed Central ID:: PMC8386138
DOI:: 10.1016/j.ydbio.2021.06.005
PMID:: 34146533
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Recent advances in high throughput single-cell RNA sequencing (scRNA-seq) technology have enabled the simultaneous transcriptomic profiling of thousands of individual cells in a single experiment. To investigate the intrinsic process of retinal development, researchers have leveraged this technology to quantify gene expression in retinal cells across development, in multiple species, and from numerous important models of human disease. In this review, we summarize recent applications of scRNA-seq and discuss how these datasets have complemented and advanced our understanding of retinal progenitor cell competence, cell fate specification, and differentiation. Finally, we also highlight the outstanding questions in the field that advances in single-cell data generation and analysis will soon be able to answer.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)

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