Pharmacokinetics of neomycin sulfate after intravenous and oral administrations in swine.

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Tytuł:: Pharmacokinetics of neomycin sulfate after intravenous and oral administrations in swine.
Autorzy:: Liu Y; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China.
Yang Y; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China.
Cao Y; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China.
Qiu J; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China.
Kong J; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China.
Zhang L; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China.
Guo Y; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China.
Zhang M; Beijing YuanDa Spark Medicine Technology Co., Ltd, Beijing, China.
Cao X; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China.; Key Laboratory of Detection for Veterinary Drug Residues and Illegal Additives, Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China.
Zhang S; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China.; Key Laboratory of Detection for Veterinary Drug Residues and Illegal Additives, Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China.
Źródło:: Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2021 Sep; Vol. 44 (5), pp. 850-853. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Oxford, Blackwell Scientific Publications.
MeSH Terms:: Neomycin*
Tandem Mass Spectrometry*/veterinary
Administration, Oral ; Animals ; Area Under Curve ; Biological Availability ; Chromatography, High Pressure Liquid/veterinary ; Chromatography, Liquid/veterinary ; Half-Life ; Injections, Intravenous/veterinary ; Swine
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Grant Information:: Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering; Metabolic Return of Antimicrobial Drugs and Environmental Micro-ecological Rise Assessment Foundation of China
Contributed Indexing:: Keywords: bioavailability; intravenous administration; neomycin sulfate; oral administration; pharmacokinetics
Substance Nomenclature:: I16QD7X297 (Neomycin)
Entry Date(s):: Date Created: 20210624 Date Completed: 20211124 Latest Revision: 20211124
Update Code:: 20240105
DOI:: 10.1111/jvp.12981
PMID:: 34165196
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The aminoglycoside antibiotic neomycin, which is used to treat external or internal bacterial infections, is primarily administered in veterinary medicine as a sulfate salt. However, no information is available on the pharmacokinetic characteristics and absolute availability of neomycin sulfate after intravenous (i.v.) and oral (p.o.) administrations in swine. Here, these parameters were studied in swine after i.v. and p.o. doses of single 15 mg/kg body weight doses. The blood samples were assessed using ultra-high-performance liquid chromatography-tandem mass/mass spectrometry (UPLC-MS/MS) and pharmacokinetic parameters were analyzed using a non-compartmental model. In swine, after the p.o. administration, the elimination half-life, mean residue time from t0 to the last collection point, mean maximum concentration, mean time to reach maximum concentration and area under concentration-time curve from t0 to the last collection point values were 12.43 ± 7.63 h, 10.25 ± 4.32 h, 0.11 ± 0.07 μg/ml, 1.92 ± 0.97 h and 1.23 ± 0.78 μg·h/ml, respectively, whereas after the i.v. administration, the values were 5.87 ± 1.12 h, 6.07 ± 0.49 h, 15.80 ± 1.32 μg/ml, 0.30 ± 0.38 h and 76.14 ± 3.52 μg·h/ml, respectively. The absolute bioavailability of neomycin sulfate B was 4.84%±0.03.
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