-
Tytuł:
-
Adult hippocampal neurogenesis in the context of lipopolysaccharide-induced neuroinflammation: A molecular, cellular and behavioral review.
-
Autorzy:
-
Domínguez-Rivas E; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Ávila-Muñoz E; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Schwarzacher SW; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt am Main, Germany.
Zepeda A; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt am Main, Germany. Electronic address: .
-
Źródło:
-
Brain, behavior, and immunity [Brain Behav Immun] 2021 Oct; Vol. 97, pp. 286-302. Date of Electronic Publication: 2021 Jun 24.
-
Typ publikacji:
-
Journal Article; Research Support, Non-U.S. Gov't; Review
-
Język:
-
English
-
Imprint Name(s):
-
Publication: <2000- > : Amsterdam : Elsevier
Original Publication: San Diego : Academic Press, [c1987-
-
MeSH Terms:
-
Lipopolysaccharides*
Neural Stem Cells*
Dentate Gyrus ; Hippocampus ; Neurogenesis
-
Contributed Indexing:
-
Keywords: Aging; Brain inflammation; Brain pathology; Cognitive deficits; Neural plasticity; Neural precursor cells
-
Substance Nomenclature:
-
0 (Lipopolysaccharides)
-
Entry Date(s):
-
Date Created: 20210626 Date Completed: 20210922 Latest Revision: 20211119
-
Update Code:
-
20240105
-
DOI:
-
10.1016/j.bbi.2021.06.014
-
PMID:
-
34174334
-
The continuous generation of new neurons occurs in at least two well-defined niches in the adult rodent brain. One of these areas is the subgranular zone of the dentate gyrus (DG) in the hippocampus. While the DG is associated with contextual and spatial learning and memory, hippocampal neurogenesis is necessary for pattern separation. Hippocampal neurogenesis begins with the activation of neural stem cells and culminates with the maturation and functional integration of a portion of the newly generated glutamatergic neurons into the hippocampal circuits. The neurogenic process is continuously modulated by intrinsic factors, one of which is neuroinflammation. The administration of lipopolysaccharide (LPS) has been widely used as a model of neuroinflammation and has yielded a body of evidence for unveiling the detrimental impact of inflammation upon the neurogenic process. This work aims to provide a comprehensive overview of the current knowledge on the effects of the systemic and central administration of LPS upon the different stages of neurogenesis and discuss their effects at the molecular, cellular, and behavioral levels.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Erratum in: Brain Behav Immun. 2022 Jan;99:412. (PMID: 34794849)
