-
Tytuł:
-
Early extubation with immediate non-invasive ventilation versus standard weaning in intubated patients for coronavirus disease 2019: a retrospective multicenter study.
-
Autorzy:
-
Cammarota G; Dipartimento di Medicina e Chirurgia, Università degli Studi di Perugia, Perugia, Italy. .
Vaschetto R; Department of Anesthesia and Intensive Care, AAzienda Ospedaliero Universitaria 'Maggiore della Carità', Novara, Italy.; Translational Medicine Department, Università 'del Piemonte Orientale', Novara, Italy.
Azzolina D; Translational Medicine Department, Università 'del Piemonte Orientale', Novara, Italy.
De Vita N; Translational Medicine Department, Università 'del Piemonte Orientale', Novara, Italy.
Olivieri C; Anesthesia and Intensive Care, Ospedale Sant'Andrea', Vercelli, Italy.
Ronco C; Anesthesia and Intensive Care, Ospedale Sant'Andrea', Vercelli, Italy.
Longhini F; Department of Medical and Surgical Science, Università 'Magna Graecia', Catanzaro, Italy.
Bruni A; Department of Medical and Surgical Science, Università 'Magna Graecia', Catanzaro, Italy.
Colombo D; Department of Anesthesia and Critical Care, Ospedale 'Ss. Trinità', Borgomanero, Italy.
Pissaia C; Department of Anesthesia and Critical Care, Ospedale 'degli Infermi', Biella, Italy.
Prato F; Department of Anesthesia and Critical Care, Ospedale 'degli Infermi', Biella, Italy.
Maestrone C; Department of Anesthesia and Critical Care, Presidio Ospedaliero Domodossola e Verbania 'ASL VCO', Domodossola-Verbania, Italy.
Maestrone M; Department of Anesthesia and Critical Care, Presidio Ospedaliero Domodossola e Verbania 'ASL VCO', Domodossola-Verbania, Italy.
Vetrugno L; Department of Medicine, Anesthesia and Intensive Care Clinic, Università di Udine, Udine, Italy.
Bove T; Department of Medicine, Anesthesia and Intensive Care Clinic, Università di Udine, Udine, Italy.
Lemut F; Department of Anesthesia and Critical Care, Ospedale 'Monsignor Giovanni Galliano', Acqui Terme, Italy.
Taretto E; Department of Anesthesia and Critical Care, Ospedale 'Monsignor Giovanni Galliano', Acqui Terme, Italy.
Locatelli A; Department of Anesthesia and Critical Care, Azienda Ospedaliera 'Santa Croce e Carle', Cuneo, Italy.
Barzaghi N; Department of Anesthesia and Critical Care, Azienda Ospedaliera 'Santa Croce e Carle', Cuneo, Italy.
Cerrano M; Department of Anesthesia and Critical Care, Azienda Ospedaliera 'Santa Croce e Carle', Cuneo, Italy.
Ravera E; Department of Emergency Medicine-Anesthesia and Critical Care-Michele, Pietro Ferrero Hospital, Verduno, Italy.
Zanza C; Department of Emergency Medicine-Anesthesia and Critical Care-Michele, Pietro Ferrero Hospital, Verduno, Italy.; Department of Anesthesia and Intensive Care, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Selva AD; Department of Emergency Medicine-Anesthesia and Critical Care-Michele, Pietro Ferrero Hospital, Verduno, Italy.
Blangetti I; Department of Anesthesia and Intensive Care, Ospedale 'Regina Montis Regalis', Mondovì, Italy.
Salvo F; Department of Anesthesia and Intensive Care, Ospedale 'Regina Montis Regalis', Mondovì, Italy.
Racca F; Department of Anesthesia and Intensive Care, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Longhitano Y; Department of Anesthesia and Intensive Care, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Boscolo A; Anesthesia and Intensive Care Unit, Ospedale Universitario di Padova, Padova, Italy.
Sguazzotti I; Department of Anesthesia and Intensive Care, AAzienda Ospedaliero Universitaria 'Maggiore della Carità', Novara, Italy.
Bonato V; Department of Anesthesia and Intensive Care, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Grossi F; Department of Anesthesia and Intensive Care, AAzienda Ospedaliero Universitaria 'Maggiore della Carità', Novara, Italy.
Crimaldi F; Translational Medicine Department, Università 'del Piemonte Orientale', Novara, Italy.
Perucca R; Department of Anesthesia and Intensive Care, AAzienda Ospedaliero Universitaria 'Maggiore della Carità', Novara, Italy.
Boniolo E; Translational Medicine Department, Università 'del Piemonte Orientale', Novara, Italy.
Verdina F; Translational Medicine Department, Università 'del Piemonte Orientale', Novara, Italy.
Vignazia GL; Department of Anesthesia and Intensive Care, AAzienda Ospedaliero Universitaria 'Maggiore della Carità', Novara, Italy.
Santangelo E; Translational Medicine Department, Università 'del Piemonte Orientale', Novara, Italy.
Tarquini R; Translational Medicine Department, Università 'del Piemonte Orientale', Novara, Italy.
Zanoni M; Department of Anesthesia and Intensive Care, AAzienda Ospedaliero Universitaria 'Maggiore della Carità', Novara, Italy.
Messina A; Humanitas, Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Marin M; Department of Medicine, Anesthesia and Intensive Care Clinic, Università di Udine, Udine, Italy.
Bacigalupo P; Department of Anesthesia and Critical Care, Ospedale 'Monsignor Giovanni Galliano', Acqui Terme, Italy.
Sileci G; Department of Anesthesia and Critical Care, Ospedale 'Monsignor Giovanni Galliano', Acqui Terme, Italy.
Sella N; Department of Medicine-DIMED, Università di Padova, Padova, Italy.
De Robertis E; Dipartimento di Medicina e Chirurgia, Università degli Studi di Perugia, Perugia, Italy.
Corte FD; Department of Anesthesia and Intensive Care, AAzienda Ospedaliero Universitaria 'Maggiore della Carità', Novara, Italy.; Translational Medicine Department, Università 'del Piemonte Orientale', Novara, Italy.
Navalesi P; Anesthesia and Intensive Care Unit, Ospedale Universitario di Padova, Padova, Italy.; Department of Medicine-DIMED, Università di Padova, Padova, Italy.
-
Źródło:
-
Scientific reports [Sci Rep] 2021 Jun 28; Vol. 11 (1), pp. 13418. Date of Electronic Publication: 2021 Jun 28.
-
Typ publikacji:
-
Journal Article; Multicenter Study
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: London : Nature Publishing Group, copyright 2011-
-
MeSH Terms:
-
COVID-19/*pathology
Noninvasive Ventilation/*methods
Ventilator Weaning/*methods
Aged ; COVID-19/mortality ; COVID-19/virology ; Comorbidity ; Female ; Hospital Mortality ; Humans ; Intensive Care Units ; Kaplan-Meier Estimate ; Length of Stay ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2/isolation & purification ; Time Factors ; Tracheostomy
-
References:
-
JAMA. 2020 Aug 25;324(8):782-793. (PMID: 32648899)
JAMA. 2020 Mar 17;323(11):1061-1069. (PMID: 32031570)
Intensive Care Med. 2020 Jul;46(7):1303-1325. (PMID: 32514598)
Eur Respir J. 2020 May 21;55(5):. (PMID: 32265307)
JAMA. 2019 Jun 11;321(22):2175-2182. (PMID: 31184740)
Cochrane Database Syst Rev. 2013 Dec 09;(12):CD004127. (PMID: 24323843)
Minerva Anestesiol. 2009 Jan-Feb;75(1-2):31-6. (PMID: 18421257)
Ann Intensive Care. 2020 Jun 9;10(1):78. (PMID: 32519064)
Br J Anaesth. 2018 Jan;120(1):18-27. (PMID: 29397127)
Nature. 2020 Mar;579(7798):270-273. (PMID: 32015507)
Eur Respir J. 2007 May;29(5):1033-56. (PMID: 17470624)
Intensive Care Med. 2012 Oct;38(10):1599-606. (PMID: 22825283)
Lancet Respir Med. 2020 Aug;8(8):816-821. (PMID: 32645311)
Am J Respir Crit Care Med. 2017 Jun 1;195(11):1477-1485. (PMID: 27768396)
Lancet. 2020 Mar 28;395(10229):1054-1062. (PMID: 32171076)
Intensive Care Med. 2019 Jan;45(1):62-71. (PMID: 30535516)
Crit Care Med. 2005 Nov;33(11):2465-70. (PMID: 16276167)
Prehosp Disaster Med. 2020 Aug;35(4):431-433. (PMID: 32423513)
JAMA. 2019 Oct 15;322(15):1465-1475. (PMID: 31577036)
Am J Respir Crit Care Med. 2013 Jul 15;188(2):220-30. (PMID: 23631814)
Crit Care. 2013 Mar 04;17(2):R39. (PMID: 23497557)
Am J Respir Crit Care Med. 2013 Jun 15;187(12):1294-302. (PMID: 23641924)
Eur Respir J. 2017 Aug 31;50(2):. (PMID: 28860265)
JAMA. 2020 Jun 9;323(22):2329-2330. (PMID: 32329799)
-
Entry Date(s):
-
Date Created: 20210629 Date Completed: 20210708 Latest Revision: 20231107
-
Update Code:
-
20240105
-
PubMed Central ID:
-
PMC8239031
-
DOI:
-
10.1038/s41598-021-92960-z
-
PMID:
-
34183764
-
In patients intubated for hypoxemic acute respiratory failure (ARF) related to novel coronavirus disease (COVID-19), we retrospectively compared two weaning strategies, early extubation with immediate non-invasive ventilation (NIV) versus standard weaning encompassing spontaneous breathing trial (SBT), with respect to IMV duration (primary endpoint), extubation failures and reintubations, rate of tracheostomy, intensive care unit (ICU) length of stay and mortality (additional endpoints). All COVID-19 adult patients, intubated for hypoxemic ARF and subsequently extubated, were enrolled. Patients were included in two groups, early extubation followed by immediate NIV application, and conventionally weaning after passing SBT. 121 patients were enrolled and analyzed, 66 early extubated and 55 conventionally weaned after passing an SBT. IMV duration was 9 [6-11] days in early extubated patients versus 11 [6-15] days in standard weaning group (p = 0.034). Extubation failures [12 (18.2%) vs. 25 (45.5%), p = 0.002] and reintubations [12 (18.2%) vs. 22 (40.0%) p = 0.009] were fewer in early extubation compared to the standard weaning groups, respectively. Rate of tracheostomy, ICU mortality, and ICU length of stay were no different between groups. Compared to standard weaning, early extubation followed by immediate NIV shortened IMV duration and reduced the rate of extubation failure and reintubation.
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.
