Detection of Crimean-Congo hemorrhagic fever virus in blood-fed Hyalomma ticks collected from Mauritanian livestock.

Tytuł:: Detection of Crimean-Congo hemorrhagic fever virus in blood-fed Hyalomma ticks collected from Mauritanian livestock.
Autorzy:: Schulz A; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany.
Barry Y; Office National de Recherches et de Développement de l'Elevage (ONARDEL), Nouakchott, Mauritania.
Stoek F; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany.
Pickin MJ; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany.
Ba A; Office National de Recherches et de Développement de l'Elevage (ONARDEL), Nouakchott, Mauritania.
Chitimia-Dobler L; Bundeswehr Institute of Microbiology, Neuherbergstrasse 11, 80937, Munich, Germany.
Haki ML; Office National de Recherches et de Développement de l'Elevage (ONARDEL), Nouakchott, Mauritania.
Doumbia BA; Ministère du Développement Rural, Nouakchott, Mauritania.
Eisenbarth A; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany.
Diambar A; Office National de Recherches et de Développement de l'Elevage (ONARDEL), Nouakchott, Mauritania.
Bah MY; Ministère du Développement Rural, Nouakchott, Mauritania.
Eiden M; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany.
Groschup MH; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany. .
Źródło:: Parasites & vectors [Parasit Vectors] 2021 Jun 29; Vol. 14 (1), pp. 342. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : BioMed Central
MeSH Terms:: Blood*
Hemorrhagic Fever Virus, Crimean-Congo/*genetics
Livestock/*parasitology
Ticks/*virology
Animals ; Camelus/parasitology ; Camelus/virology ; Cattle/parasitology ; Cattle/virology ; Feeding Behavior ; Female ; Genotype ; Hemorrhagic Fever Virus, Crimean-Congo/isolation & purification ; Hemorrhagic Fever, Crimean/virology ; Livestock/virology ; Male ; Mauritania ; Phylogeny ; RNA, Viral/genetics ; Ticks/genetics ; Ticks/physiology
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Grant Information:: GR 980/4-1 DFG; ID 222 European Union
Contributed Indexing:: Keywords: Crimean-Congo hemorrhagic fever virus; Epidemiology; Hyalomma species; Livestock; Mauritania
Substance Nomenclature:: 0 (RNA, Viral)
Entry Date(s):: Date Created: 20210630 Date Completed: 20211105 Latest Revision: 20211126
Update Code:: 20240105
PubMed Central ID:: PMC8244218
DOI:: 10.1186/s13071-021-04819-x
PMID:: 34187526
: Czasopismo naukowe

Pełny tekst

Background: Crimean-Congo hemorrhagic fever virus (CCHFV) belongs to the genus Orthonairovirus (Nairovididae) and is a (re)emerging tick-borne pathogen. It is endemic in most parts of Africa, Asia and southern Europe, and can cause severe hemorrhagic symptoms in humans, with high fatality rates (5-30%).
Methods: Hyalomma ticks were collected from four different livestock herds (cattle and camels) in Mauritania in 2018. The tick species were determined morphologically and confirmed molecularly by using the cytochrome oxidase 1 gene marker. For the detection of CCHFV, ticks were tested individually by one-step multiplex real-time reverse-transcriptase quantitative polymerase chain reaction. The small segment of all positive samples was sequenced to determine the CCHFV genotype.
Results: In total, 39 of the 1523 ticks (2.56%) collected from 63 cattles and 28 camels tested positive for CCHFV. Three Hyalomma species were identified. Hyalomma rufipes had the largest proportion of positivity (5.67%; 16/282), followed by Hyalomma dromedarii (1.89%; 23/1214). No Hyalomma impeltatum tested positive (0%; 0/21). Positive ticks were found in only six out of 91 host animals. Viral sequence analysis revealed the presence of two different CCHFV lineages (Africa I and Africa III).
Conclusions: In this study, 2.56% of Hyalomma ticks collected from camels and cattle in Mauritania tested positive for CCHFV. However, the true prevalence of CCHFV in unfed ticks may be lower, as a considerable number of ticks may have been passively infected during blood-feeding by co-feeding ticks or due to viremia of the host. The results indicate the need to track the actual area of circulation of this virus.

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