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Tytuł pozycji:

Evidence for a chromosome origin unwinding system broadly conserved in bacteria.

Tytuł:
Evidence for a chromosome origin unwinding system broadly conserved in bacteria.
Autorzy:
Pelliciari S; Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne NE2 4AX, UK.
Dong MJ; Department of Physics, School of Science, Tianjin University, Tianjin, China.; Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, China.
Gao F; Department of Physics, School of Science, Tianjin University, Tianjin, China.; Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, China.
Murray H; Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne NE2 4AX, UK.
Źródło:
Nucleic acids research [Nucleic Acids Res] 2021 Jul 21; Vol. 49 (13), pp. 7525-7536.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
MeSH Terms:
Chromosomes, Bacterial*
Origin Recognition Complex*
Replication Origin*
Bacteria/*genetics
Bacillus subtilis/genetics ; Bacteria/metabolism ; Bacterial Proteins/metabolism ; DNA-Binding Proteins/metabolism ; Gram-Negative Bacteria/genetics ; Gram-Positive Bacteria/genetics ; Helicobacter pylori/genetics ; Microbial Viability ; Nucleotide Motifs
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Grant Information:
BB/P018432/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; United Kingdom WT_ Wellcome Trust; 204985/Z/16/Z United Kingdom WT_ Wellcome Trust
Substance Nomenclature:
0 (Bacterial Proteins)
0 (DNA-Binding Proteins)
0 (DnaA protein, Bacteria)
0 (OriC chromosomal replication origin)
0 (Origin Recognition Complex)
Entry Date(s):
Date Created: 20210701 Date Completed: 20210809 Latest Revision: 20210809
Update Code:
20240105
PubMed Central ID:
PMC8287927
DOI:
10.1093/nar/gkab560
PMID:
34197592
Czasopismo naukowe
Genome replication is a fundamental requirement for the proliferation of all cells. Throughout the domains of life, conserved DNA replication initiation proteins assemble at specific chromosomal loci termed replication origins and direct loading of replicative helicases (1). Despite decades of study on bacterial replication, the diversity of bacterial chromosome origin architecture has confounded the search for molecular mechanisms directing the initiation process. Recently a basal system for opening a bacterial chromosome origin (oriC) was proposed (2). In the model organism Bacillus subtilis, a pair of double-stranded DNA (dsDNA) binding sites (DnaA-boxes) guide the replication initiator DnaA onto adjacent single-stranded DNA (ssDNA) binding motifs (DnaA-trios) where the protein assembles into an oligomer that stretches DNA to promote origin unwinding. We report here that these core elements are predicted to be present in the majority of bacterial chromosome origins. Moreover, we find that the principle activities of the origin unwinding system are conserved in vitro and in vivo. The results suggest that this basal mechanism for oriC unwinding is broadly functionally conserved and therefore may represent an ancestral system to open bacterial chromosome origins.
(© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.)

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