Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar.

Tytuł:: Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar.
Autorzy:: Solofomalala AHD; Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar.
Rajemiarimoelisoa CF; Pharmacy Department, Faculty of Medicine, University of Antananarivo, P.O. Box 375, Antananarivo 101, Madagascar.
Judicael RL; Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar.
Randrianarivo HR; Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar.
Rakoto DAD; Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar.
Jeannoda VL; Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar.
Boumendjel A; Univ. Grenoble Alpes, INSERM, LRB, 38000 Grenoble, France.; Univ. Grenoble Alpes, CNRS, DPM, 38000 Grenoble, France.
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Jun 07; Vol. 26 (11). Date of Electronic Publication: 2021 Jun 07.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, c1995-
MeSH Terms:: Alkaloids/*chemistry
Beverages/*analysis
Crotalaria/*chemistry
Fabaceae/*chemistry
Pyrrolizidine Alkaloids/*chemistry
Seeds/*chemistry
Madagascar
References:: Toxicon. 2005 Mar 1;45(3):347-52. (PMID: 15683873)
Nat Prod Res. 2016 Jul;30(13):1557-60. (PMID: 26571367)
J Tradit Complement Med. 2018 Aug 09;8(4):451-458. (PMID: 30302325)
J Pharm Sci. 1966 Mar;55(3):225-76. (PMID: 5335471)
Food Chem Toxicol. 2020 Feb;136:111107. (PMID: 31904473)
Molecules. 2019 Jan 30;24(3):. (PMID: 30704105)
J Agric Food Chem. 2009 Jan 14;57(1):311-9. (PMID: 19061310)
Planta Med. 2021 May 26;:. (PMID: 34041723)
Bioorg Med Chem Lett. 2005 May 16;15(10):2453-5. (PMID: 15929201)
J Nat Prod. 2011 Nov 28;74(11):2400-7. (PMID: 22054075)
J Clin Pathol. 2002 Sep;55(9):676-9. (PMID: 12194997)
Food Chem. 2021 Apr 16;342:128384. (PMID: 33214040)
Pharmacol Ther. 1990;47(3):371-89. (PMID: 2290854)
Vet Clin North Am Food Anim Pract. 2020 Nov;36(3):715-723. (PMID: 33032701)
J Nat Toxins. 1998 Feb;7(1):87-93. (PMID: 9689604)
J Appl Toxicol. 2010 Apr;30(3):183-96. (PMID: 20112250)
Chem Res Toxicol. 2014 Jun 16;27(6):1030-9. (PMID: 24836403)
Phytochem Anal. 2020 Nov;31(6):747-755. (PMID: 32428987)
Contributed Indexing:: Keywords: Crotalaria; Fabaceae; alkaloids; pyrrolizidine; toxicity; traditional use; usaramine
Substance Nomenclature:: 0 (Alkaloids)
0 (Pyrrolizidine Alkaloids)
Entry Date(s):: Date Created: 20210702 Date Completed: 20210713 Latest Revision: 20210713
Update Code:: 20240105
PubMed Central ID:: PMC8201287
DOI:: 10.3390/molecules26113464
PMID:: 34200328
: Czasopismo naukowe

Pełny tekst

Seeds of Crotalaria cleomifolia (Fabaceae) are consumed in Madagascar in preparation of popular beverages. The investigation of extracts from the seeds of this species revealed the presence of high amounts of alkaloids from which two pyrrolizidine-derived alkaloids were isolated. One of them was fully characterized by spectroscopic and spectrometric methods, which was found to be usaramine. Owing to the high toxicity of these alkaloids, issuing a strong warning among populations consuming the seeds of Crotalaria cleomifolia must be considered.

Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Informacja