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Tytuł pozycji:

Cissus verticillata Extract Decreases Neuronal Damage Induced by Oxidative Stress in HT22 Cells and Ischemia in Gerbils by Reducing the Inflammation and Phosphorylation of MAPKs.

Tytuł:
Cissus verticillata Extract Decreases Neuronal Damage Induced by Oxidative Stress in HT22 Cells and Ischemia in Gerbils by Reducing the Inflammation and Phosphorylation of MAPKs.
Autorzy:
Kim W; Department of Biomedical Sciences, and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.; Department of Anatomy, College of Veterinary Medicine, Veterinary Science Research Institute, Konkuk University, Seoul 05030, Korea.
Kwon HJ; Department of Biomedical Sciences, and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.; Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung 25457, Korea.
Jung HY; Department of Veterinary Medicine, Institute of Veterinary Science, Chungnam National University, Daejeon 34134, Korea.
Lim SS; Department of Food Science and Nutrition, Institute of Korean Nutrition, Hallym University, Chuncheon 24252, Korea.
Kang BG; Department of Biochemistry, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Jo YB; Department of Convergence Technology, Graduate School of Venture, Hoseo University, Seoul 06724, Korea.
Yu DS; Department of Venture Management Graduate School of Venture, Hoseo University, Seoul 06724, Korea.
Choi SY; Department of Biomedical Sciences, and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Hwang IK; Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.
Kim DW; Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung 25457, Korea.
Źródło:
Plants (Basel, Switzerland) [Plants (Basel)] 2021 Jun 15; Vol. 10 (6). Date of Electronic Publication: 2021 Jun 15.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI AG, [2012]-
References:
Neurosci Lett. 2011 Oct 31;504(3):223-7. (PMID: 21964380)
Cells. 2020 Sep 23;9(10):. (PMID: 32977412)
Mol Neurobiol. 2001 Feb;23(1):1-19. (PMID: 11642541)
J Stroke Cerebrovasc Dis. 2020 May;29(5):104773. (PMID: 32199775)
Biotechnol Appl Biochem. 2003 Feb;37(Pt 1):15-20. (PMID: 12578546)
Saudi J Biol Sci. 2020 May;27(5):1302-1309. (PMID: 32346339)
Int J Mol Sci. 2016 Jan 23;17(2):. (PMID: 26805827)
Physiol Rev. 1999 Oct;79(4):1431-568. (PMID: 10508238)
Nutrients. 2021 Jan 08;13(1):. (PMID: 33435613)
Neuroscience. 2021 Jan 15;453:256-265. (PMID: 33220187)
Life Sci. 2004 Sep 3;75(16):1989-2001. (PMID: 15306166)
Pharmacol Res. 2006 Mar;53(3):303-9. (PMID: 16459097)
Evid Based Complement Alternat Med. 2012;2012:135379. (PMID: 22991570)
Pediatr Res. 2007 Mar;61(3):295-300. (PMID: 17314686)
Exp Biol Med (Maywood). 2019 Nov;244(16):1463-1474. (PMID: 31583895)
Int J Mol Med. 2014 Oct;34(4):1159-68. (PMID: 25090966)
J Neurochem. 2005 Mar;92(5):1054-60. (PMID: 15715656)
Curr Neuropharmacol. 2018;16(9):1396-1415. (PMID: 29512465)
Food Funct. 2013 Feb;4(2):338-46. (PMID: 23175101)
Chem Pharm Bull (Tokyo). 2009 Oct;57(10):1089-95. (PMID: 19801863)
Acta Pharmacol Sin. 2017 Apr;38(4):445-458. (PMID: 28260801)
Biomed Pharmacother. 2020 May;125:109990. (PMID: 32070874)
Front Mol Neurosci. 2020 Mar 05;13:28. (PMID: 32194375)
J Med Food. 2009 Oct;12(5):990-5. (PMID: 19857061)
Int J Mol Med. 2002 Aug;10(2):131-6. (PMID: 12119547)
Food Funct. 2020 Sep 23;11(9):7842-7855. (PMID: 32812575)
Phytomedicine. 2015 Sep 15;22(10):952-60. (PMID: 26321745)
Front Pharmacol. 2018 Jul 17;9:751. (PMID: 30065650)
Genes Environ. 2019 Dec 11;41:22. (PMID: 31890055)
J Neurochem. 2007 Mar;100(6):1703-12. (PMID: 17217415)
J Vet Sci. 2018 Jul 31;19(4):505-511. (PMID: 29695143)
Neurochem Int. 2018 Sep;118:265-274. (PMID: 29753754)
Brain Struct Funct. 2016 Sep;221 Suppl 1:1-272. (PMID: 27507296)
Neurochem Int. 2020 Feb;133:104631. (PMID: 31836547)
J Med Food. 2018 Jun;21(6):596-604. (PMID: 29847228)
J Ethnopharmacol. 2012 Sep 28;143(2):664-72. (PMID: 22902249)
J Neuroinflammation. 2008 Oct 23;5:46. (PMID: 18947400)
Phytomedicine. 2012 Jan 15;19(2):150-9. (PMID: 21778042)
Med Sci Monit. 2018 Nov 14;24:8198-8206. (PMID: 30428482)
Neural Regen Res. 2017 Feb;12(2):220-227. (PMID: 28400803)
Biomed Pharmacother. 2016 Jul;81:416-423. (PMID: 27261621)
Redox Rep. 2014 Sep;19(5):214-20. (PMID: 24946070)
Drug Des Devel Ther. 2015 Jun 05;9:2927-40. (PMID: 26089642)
Metab Brain Dis. 2020 Jun;35(5):841-848. (PMID: 32212043)
Oxid Med Cell Longev. 2019 May 16;2019:8512048. (PMID: 31223427)
Brain Res Mol Brain Res. 2003 Feb 20;110(2):245-52. (PMID: 12591160)
PLoS One. 2021 Mar 18;16(3):e0248689. (PMID: 33735236)
Sci Rep. 2021 Jan 21;11(1):2008. (PMID: 33479386)
J Ethnopharmacol. 2000 Aug;71(3):395-400. (PMID: 10940576)
Neurotox Res. 2020 Mar;37(3):525-542. (PMID: 31960265)
J Neurosci. 2004 Jan 21;24(3):671-8. (PMID: 14736853)
Oxid Med Cell Longev. 2019 Oct 13;2019:5080843. (PMID: 31737171)
Chem Biol Interact. 2006 Jul 10;161(3):262-70. (PMID: 16797507)
BMC Pharmacol. 2004 Jun 08;4:9. (PMID: 15182373)
Minim Invasive Neurosurg. 2008 Apr;51(2):87-90. (PMID: 18401820)
Int J Mol Sci. 2010 Feb 04;11(2):622-46. (PMID: 20386657)
J Biomed Biotechnol. 2009;2009:274740. (PMID: 19300520)
Anat Rec (Hoboken). 2009 Dec;292(12):1902-13. (PMID: 19943344)
Front Pharmacol. 2020 Apr 15;11:424. (PMID: 32351385)
Neurol Res. 1997 Dec;19(6):629-33. (PMID: 9427965)
Phytother Res. 2009 Sep;23(9):1197-204. (PMID: 19140172)
Eur J Pharmacol. 2003 Apr 25;467(1-3):103-9. (PMID: 12706462)
Neural Regen Res. 2019 Aug;14(8):1394-1403. (PMID: 30964065)
Grant Information:
NRF-2019R1A6A1A11036849 Ministry of Education
Contributed Indexing:
Keywords: Cissus verticillata extract; MAPK; inflammation; ischemia; oxidative stress
Entry Date(s):
Date Created: 20210702 Latest Revision: 20210714
Update Code:
20240105
PubMed Central ID:
PMC8232592
DOI:
10.3390/plants10061217
PMID:
34203930
Czasopismo naukowe
In the present study, we examined the effects of Cissus verticillata leaf extracts (CVE) against hydrogen peroxide (H 2 O 2 )- and ischemia-induced neuronal damage in HT22 cells and gerbil hippocampus. Incubation with CVE produced concentration-dependent toxicity in HT22 cells. Significant cellular toxicity was observed with >75 μg/mL CVE. CVE treatment at 50 μg/mL ameliorated H 2 O 2 -induced reactive oxygen species formation, DNA fragmentation, and cell death in HT22 cells. In addition, incubation with CVE significantly mitigated the increase in Bax and decrease in Bcl-2 induced by H 2 O 2 treatment in HT22 cells. In an in vivo study, the administration of CVE to gerbils significantly decreased ischemia-induced motor activity 1 d after ischemia, as well as neuronal death and microglial activation 4 d after ischemia, respectively. CVE treatment reduced the release of interleukin-1β, interleukin-6, and tumor necrosis factor-α 6 h after ischemia. Furthermore, CVE treatment significantly ameliorated ischemia-induced phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase 1/2, and p38. These results suggest that CVE has the potential to reduce the neuronal damage induced by oxidative and ischemic stress by reducing the inflammatory responses and phosphorylation of MAPKs, suggesting that CVE could be a functional food to prevent neuronal damage induced by ischemia.

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