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Tytuł pozycji:

Sex and Age-Related Differences in Neuroinflammation and Apoptosis in Balb/c Mice Retina Involve Resolvin D1.

Tytuł:
Sex and Age-Related Differences in Neuroinflammation and Apoptosis in Balb/c Mice Retina Involve Resolvin D1.
Autorzy:
Trotta MC; Section of Pharmacology, Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', via Santa Maria di Costantinopoli 16, 80138 Naples, Italy.
Gharbia S; 'Aurel Ardelean' Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Revolutiei Av., 310144 Arad, Romania.
Herman H; 'Aurel Ardelean' Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Revolutiei Av., 310144 Arad, Romania.
Mladin B; 'Aurel Ardelean' Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Revolutiei Av., 310144 Arad, Romania.
Hermenean A; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Av., 050474 Bucharest, Romania.
Balta C; 'Aurel Ardelean' Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Revolutiei Av., 310144 Arad, Romania.
Cotoraci C; Faculty of Medicine, Vasile Goldis Western University of Arad, 86 Revolutiei Av., 310144 Arad, Romania.
Peteu VE; Victor Babes National Institute of Pathology, 99-101 Splaiul Independentei Av., 050096 Bucharest, Romania.
Gesualdo C; Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 6, 80138 Naples, Italy.
Petrillo F; Department of Ophthalmology, University of Catania, P.zza Università 2, 95131 Catania, Italy.
Galdiero M; Section of Pharmacology, Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', via Santa Maria di Costantinopoli 16, 80138 Naples, Italy.
Alfano R; Department of Advanced Medical and Surgical Sciences 'DAMSS', University of Campania 'Luigi Vanvitelli', P.zza L. Miraglia 2, 80138 Naples, Italy.
Gherghiceanu M; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Av., 050474 Bucharest, Romania.; Victor Babes National Institute of Pathology, 99-101 Splaiul Independentei Av., 050096 Bucharest, Romania.
D'Amico M; Section of Pharmacology, Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', via Santa Maria di Costantinopoli 16, 80138 Naples, Italy.
Rossi S; Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 6, 80138 Naples, Italy.
Hermenean A; 'Aurel Ardelean' Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Revolutiei Av., 310144 Arad, Romania.; Faculty of Medicine, Vasile Goldis Western University of Arad, 86 Revolutiei Av., 310144 Arad, Romania.
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 11; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 11.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:
Sex Characteristics*
Aging/*pathology
Docosahexaenoic Acids/*pharmacology
Inflammation/*pathology
Retina/*pathology
Animals ; Apoptosis/drug effects ; Biomarkers/metabolism ; Caspase 3/metabolism ; Ependymoglial Cells/drug effects ; Ependymoglial Cells/metabolism ; Ependymoglial Cells/pathology ; Ependymoglial Cells/ultrastructure ; Female ; Male ; Mice, Inbred BALB C ; Microglia/drug effects ; Microglia/metabolism ; Microglia/pathology ; Microglia/ultrastructure ; NF-kappa B/metabolism ; Retina/drug effects ; Tumor Necrosis Factor-alpha/metabolism ; Tyrosine/analogs & derivatives ; Tyrosine/metabolism ; Mice
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Grant Information:
PRIN - 2017TSHBXZ Ministero dell'Istruzione, dell'Università e della Ricerca; PN 1N/2019_19.29.01.02 Ministerul Cercetării şi Inovării; 7PFE/2018 Ministerul Cercetării şi Inovării
Contributed Indexing:
Keywords: aging; apoptosis; neuroprotection; retina
Substance Nomenclature:
0 (Biomarkers)
0 (NF-kappa B)
0 (Tumor Necrosis Factor-alpha)
0 (resolvin D1)
25167-62-8 (Docosahexaenoic Acids)
3604-79-3 (3-nitrotyrosine)
42HK56048U (Tyrosine)
EC 3.4.22.- (Caspase 3)
Entry Date(s):
Date Created: 20210702 Date Completed: 20210714 Latest Revision: 20240226
Update Code:
20240226
PubMed Central ID:
PMC8230628
DOI:
10.3390/ijms22126280
PMID:
34208040
Czasopismo naukowe
(1) Background: The pro-resolving lipid mediator Resolvin D1 (RvD1) has already shown protective effects in animal models of diabetic retinopathy. This study aimed to investigate the retinal levels of RvD1 in aged (24 months) and younger (3 months) Balb/c mice, along with the activation of macro- and microglia, apoptosis, and neuroinflammation. (2) Methods: Retinas from male and female mice were used for immunohistochemistry, immunofluorescence, transmission electron microscopy, Western blotting, and enzyme-linked immunosorbent assays. (3) Results: Endogenous retinal levels of RvD1 were reduced in aged mice. While RvD1 levels were similar in younger males and females, they were markedly decreased in aged males but less reduced in aged females. Both aged males and females showed a significant increase in retinal microglia activation compared to younger mice, with a more marked reactivity in aged males than in aged females. The same trend was shown by astrocyte activation, neuroinflammation, apoptosis, and nitrosative stress, in line with the microglia and Müller cell hypertrophy evidenced in aged retinas by electron microscopy. (4) Conclusions: Aged mice had sex-related differences in neuroinflammation and apoptosis and low retinal levels of endogenous RvD1.

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