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Tytuł:
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Neutrophil extracellular traps in cattle health and disease.
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Autorzy:
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Xie L; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
Ma Y; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
Opsomer G; Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
Pascottini OB; Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium; Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, 2610 Wilrijk, Belgium.
Guan Y; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
Dong Q; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China. Electronic address: .
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Źródło:
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Research in veterinary science [Res Vet Sci] 2021 Oct; Vol. 139, pp. 4-10. Date of Electronic Publication: 2021 Jun 25.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: London : British Veterinary Association
Original Publication: Oxford.
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MeSH Terms:
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Cattle Diseases*/immunology
Extracellular Traps*
Animals ; Cattle ; Humans ; Neutrophils ; Phagocytosis
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Contributed Indexing:
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Keywords: Cattle; Disease; Inflammation; Innate immunity; Neutrophil extracellular traps
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Entry Date(s):
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Date Created: 20210704 Date Completed: 20211005 Latest Revision: 20211005
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Update Code:
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20240105
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DOI:
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10.1016/j.rvsc.2021.06.019
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PMID:
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34217982
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Neutrophils largely contribute to the first line of defense against the invasion of pathogens. They kill pathogens basically by the following mechanisms: phagocytosis and proteolytic degradation, the release of enzymes with bactericidal activities, and the production of fibers to entrap pathogens, also known as neutrophil extracellular traps (NETs). NETs capture pathogens as a mechanism of immune protection and have been studied in-depth in various fields of human medicine. However, research about NETs in cattle is relatively scarce. The present article reviews the generation mechanisms, structural composition, signal pathways, advantages (and disadvantages) of NETs, and summarizes the latest findings of NETs in cattle health and disease.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)