Clinical and molecular epidemiological characterization of rotavirus infections in children under five years old in Shandong province, China.

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Tytuł:: Clinical and molecular epidemiological characterization of rotavirus infections in children under five years old in Shandong province, China.
Autorzy:: Dong S; Department of Intensive Care Unit, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Wenhua Xi Road 107, Ji'nan, 250012, Shandong, China.
Huang D; Department of Infectious Diseases, Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266000, Shandong, China.
Wang Z; Department of Infectious Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Wenhua Xi Road 107, Ji'nan, 250012, Shandong, China.
Zhang G; Department of Infectious Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Wenhua Xi Road 107, Ji'nan, 250012, Shandong, China.
Zhang F; Department of Infectious Diseases, Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266000, Shandong, China.
Sai L; Department of Infectious Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Wenhua Xi Road 107, Ji'nan, 250012, Shandong, China. .
Źródło:: Archives of virology [Arch Virol] 2021 Sep; Vol. 166 (9), pp. 2479-2486. Date of Electronic Publication: 2021 Jul 04.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Wien, New York, Springer-Verlag.
MeSH Terms:: Molecular Epidemiology*
Rotavirus/*genetics
Rotavirus Infections/*epidemiology
Rotavirus Infections/*virology
Child, Preschool ; China/epidemiology ; Diarrhea/virology ; Female ; Gastroenteritis/virology ; Genotype ; Humans ; Immunization Programs ; Incidence ; Infant ; Male ; Prevalence ; Rotavirus Infections/physiopathology ; Rotavirus Infections/prevention & control ; Rotavirus Vaccines ; Vaccination
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Grant Information:: 2018 GSF118071 Shandong Provincial Key Research and Development Program
Substance Nomenclature:: 0 (Rotavirus Vaccines)
Entry Date(s):: Date Created: 20210704 Date Completed: 20210810 Latest Revision: 20210810
Update Code:: 20240105
DOI:: 10.1007/s00705-021-05161-4
PMID:: 34218319
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Rotaviruses are important causative agents of acute gastroenteritis in children. In China, rotavirus infection has a prevalence rate of 30% and is therefore considered a serious public health problem. This study was carried out to investigate the clinical and molecular epidemiological characteristics of rotavirus infections in children under 5 years old with acute diarrhea in Shandong province, China. From July 2017 to June 2018, a total of 1211 fecal specimens were tested, and the prevalence of rotavirus infection was 32.12%. The mean age of the infected children was 12.2 ± 10.9 months, and the highest infection rate was observed in children aged 7-12 months, with a rate of 41.64%. G9P[8] (76.61%) was the most prevalent genotype combination, followed by G2P[4] (7.20%), G3P[8] (3.60%), and G9P[4] (2.06%). In addition to diarrhea, vomiting, fever, and dehydration were the most common clinical signs. In general, there was no significant difference in clinical manifestations among different age groups. However, the clinical manifestations differed significantly between vaccinated and unvaccinated children. Vaccinated children showed lower incidence and frequency of vomiting, lower incidence and degree of dehydration, and lower incidence of severe cases than unvaccinated children. These findings suggest that it is necessary to continuously monitor changes in the characteristics of rotavirus infections. Moreover, the introduction of vaccines into the national immunization program to prevent and control rotavirus infection is needed in China.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)

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