A Study on the Bending Stiffness of a New DNA Origami Nano-Joint.

Szczegóły
Abstrakt

Tytuł:: A Study on the Bending Stiffness of a New DNA Origami Nano-Joint.
Autorzy:: Dastorani S; Department of Mechanical Engineering, Hakim Sabzevari University, Sabzevar, Iran.
Ghasemi RH; Department of Mechanical Engineering, Hakim Sabzevari University, Sabzevar, Iran. .
Soheilifard R; Department of Mechanical Engineering, Hakim Sabzevari University, Sabzevar, Iran.
Źródło:: Molecular biotechnology [Mol Biotechnol] 2021 Nov; Vol. 63 (11), pp. 1057-1067. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: [Cham] : Springer
Original Publication: Totowa, NJ : Humana Press, c1994-
MeSH Terms:: DNA/*chemistry
Nanostructures/*chemistry
Elasticity ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Nanotechnology ; Nucleic Acid Conformation
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Contributed Indexing:: Keywords: Bending stiffness; DNA origami nano-joint; Mechanical properties; Steered molecular dynamics
Substance Nomenclature:: 9007-49-2 (DNA)
Entry Date(s):: Date Created: 20210705 Date Completed: 20220214 Latest Revision: 20220214
Update Code:: 20240105
DOI:: 10.1007/s12033-021-00367-y
PMID:: 34224047
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The present article aims to investigate the mechanical properties of a new DNA origami nano-joint using the steered molecular dynamics (SMD) simulation. Since the analysis of mechanical properties is of great importance in bending conditions for a nano-joint, the forces are selected to achieve angular changes in the joint by the resultant torque. In this study, the nano-joint is considered as a beam in order to use mechanical equations to extract the mechanical properties of the designed nano-joint. In addition, the bending stiffness of the beam is investigated in different modes of deflection using the Euler-Bernoulli beam theory. The results revealed that the value of bending stiffness increases with increasing deflection, and the changes in the bending stiffness relative to the deflection is linear. The proposed DNA origami nano-joint can be used as a joint in nanorobots and can be effectively applied in nanorobotic systems to move different components.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

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