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Tytuł:
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Linh Phu Khang Tue Tinh inhibited prostate proliferation in rats induced benign prostatic hyperplasia by testosterone propionate.
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Autorzy:
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Minh TD; Vietnam University of Traditional Medicine, 2 Tranphu Street, Hadong district, Hanoi, 100000, Viet Nam; General Surgery Department, Viet Nam. Electronic address: .
Thanh Ha TN; Hospital 103, Viet Nam; Vietnam Military Medical University, 160 Phunghung, Hadong district, Hanoi, 100000, Viet Nam.
Duy TN; Vietnam University of Traditional Medicine, 2 Tranphu Street, Hadong district, Hanoi, 100000, Viet Nam; Department of Pharmacology, Viet Nam.
Hoang NN; Vietnam Military Medical University, 160 Phunghung, Hadong district, Hanoi, 100000, Viet Nam; Department of Pharmacology, Viet Nam.
PhamTien D; Department of Traditional Medicine, Haiphong University of Medicine and Pharmacy, 72A Nguyen Binh Khiem, Ngo Quyen, Hai Phong, 180000, Viet Nam.
Thai HP; Vietnam University of Traditional Medicine, 2 Tranphu Street, Hadong district, Hanoi, 100000, Viet Nam; General Surgery Department, Viet Nam.
Thi HN; Vietnam University of Traditional Medicine, 2 Tranphu Street, Hadong district, Hanoi, 100000, Viet Nam; General Surgery Department, Viet Nam.
Thi Lan PD; Vietnam University of Traditional Medicine, 2 Tranphu Street, Hadong district, Hanoi, 100000, Viet Nam; General Surgery Department, Viet Nam.
Quoc BP; Vietnam University of Traditional Medicine, 2 Tranphu Street, Hadong district, Hanoi, 100000, Viet Nam; Department of Theoretical Traditional Medicine, Viet Nam.
Ivkin DY; Department of Pharmacology and Clinical Pharmacology, Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia.
Povydysh MN; Department of Pharmacology and Clinical Pharmacology, Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia. Electronic address: .
Cong BN; Vietnam Military Medical University, 160 Phunghung, Hadong district, Hanoi, 100000, Viet Nam.
Krasnova MV; Department of Pharmacology and Clinical Pharmacology, Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia.
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Źródło:
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Journal of ethnopharmacology [J Ethnopharmacol] 2021 Oct 28; Vol. 279, pp. 114388. Date of Electronic Publication: 2021 Jul 02.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Limerick : Elsevier Sequoia
Original Publication: Lausanne, Elsevier Sequoia.
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MeSH Terms:
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Medicine, East Asian Traditional*
Prostatic Hyperplasia/*chemically induced
Prostatic Hyperplasia/*drug therapy
Testosterone Propionate/*toxicity
5-alpha Reductase Inhibitors/therapeutic use ; Animals ; Dutasteride/therapeutic use ; Male ; Quinazolines/therapeutic use ; Random Allocation ; Rats ; Rats, Wistar ; Urination/drug effects ; Urological Agents/therapeutic use ; Vietnam
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Contributed Indexing:
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Keywords: Benign prostatic hyperplasia; Linh phu khang Tue tinh; Rats
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Substance Nomenclature:
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0 (5-alpha Reductase Inhibitors)
0 (Quinazolines)
0 (Urological Agents)
90347YTW5F (alfuzosin)
O0J6XJN02I (Dutasteride)
WI93Z9138A (Testosterone Propionate)
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Entry Date(s):
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Date Created: 20210705 Date Completed: 20220106 Latest Revision: 20220106
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Update Code:
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20240105
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DOI:
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10.1016/j.jep.2021.114388
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PMID:
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34224813
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Ethnopharmacological Relevance: Benign prostatic hyperplasia (BPH) is the hyperproliferation of the stromal and the epithelial cells within the prostatic transition zone. In recent years, phytotherapy have been studied with the concern for increasing quality of life, improving lower urinary tract symptoms (LUTS) as well as reducing prostate volume and the frequency of adverse events was similar to that of placebo. Linh Phu Khang Tue Tinh (LPKTT) capsules are formulated from 4 herbs widely used in traditional Vietnamese medicine - Panax notoginseng (Burkill) F.H.Chen - Tam thất (radix), Crinum asiaticum L. - Náng hoa trắng or giant crinum lily, Polygonum cuspidatum Willd. ex Spreng. (= Reynoutria japonica Houtt) - Cốt củ khí or Japanese knotweed (radix), Oldenlandia herbacea (L.) Roxb. (formerly known as Hedyotis diffusa Spreng.) - Bạch hoa xà thiẹ^t thảo or slender oldenlandia (herb). The preparation has been used in traditional Vietnamese medicine to treat nocturia, weak urine stream, urinary tract infection. According to modern studies, these herbs have anti-inflammation, antitumor, and antioxidant activities.
Aims of the Study: Evaluating the effects of LPKTT capsules on the development of BPH using a rat model of BPH induced by testosterone propionate (TP).
Materials and Methods: 60 male Wistar rats, 10-12 weeks of age, weight 200-250 g were separated into six groups: (G1) a normal control group that was taken orally phosphate-buffered saline (p.o.; PBS.) with corn oil (subcutaneous injection- Sc); (G2) a BPH model group that received PBS (p.o) with TP (Sc); (G3) a positive control group that received dutasteride (25 μg/kg BW/24 h, p.o.) with TP (Sc); (G4) a positive control group that received alfuzosin HCl (1.8 mg/kg BW/24 h, p.o.) with TP (s.c.) and (G5 and G6) LPKTT groups that received LPKTT at 289.8 or 869.4 mg/kg(p.o.) respectively, with TP (s.c.). BPH model was induced by Sc of TP, 3 mg/kg for 4 weeks. After that, rats were received NaCl/Dutasteride/Alfuzosin/LPKTT for the next 28 days. On the 56th day, assessed the results were through the indicators: micturition frequency, voided volume, total voided volume, the prostate and body weights, the ratio of prostate weight to body weight, prostate histology.
Results: LPKTT reduced micturition frequency and increased the voided volume when compared to the control group (p < 0.01). The results were equivalent to those of the alfuzosin ones (G4). LPKTT lowered prostate weight and the ratio of prostate weight to body weight when compared to the control group (p < 0.01). These reductions were the same in the dutasteride ones. Histomorphology in G5 and G6 also showed that LPKTT inhibited TP induced prostatic hyperplasia. The results were similar to that in the dutasteride group. Microscopic images of prostate in G5 and G6 were almost similar to that of G1.
Conclusion: LPKTT capsules work to inhibit prostate proliferation in rats induced BPH by TP.
(Copyright © 2021 Elsevier B.V. All rights reserved.)