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Tytuł pozycji:

Erianin inhibits human lung cancer cell growth via PI3K/Akt/mTOR pathway in vitro and in vivo.

Tytuł :
Erianin inhibits human lung cancer cell growth via PI3K/Akt/mTOR pathway in vitro and in vivo.
Autorzy :
Zhang HQ; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xie XF; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Li GM; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chen JR; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Li MT; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xu X; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xiong QY; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chen GR; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yin YP; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Peng F; School of Pharmacy, West China School of Pharmacy, Sichuan University, Chengdu, China.
Chen Y; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Peng C; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Pokaż więcej
Źródło :
Phytotherapy research : PTR [Phytother Res] 2021 Aug; Vol. 35 (8), pp. 4511-4525. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: : Chichester : Wiley
Original Publication: London : Heyden & Son, c1987-
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Grant Information :
2020ZYD058 Central guided local special project Southwestern characteristic Chinese medicine resource genomics innovation platform; 2020YFS0053 Key R&D Project of Sichuan Provincial Department of Science and Technology: Discovery of Innovative Drug Research on Anti-Tri-negative Breast Cancer Based on the miRNA Network; 2020JCRC004 Open Research Fund of Chengdu University of Traditional Chinese Medicine Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China
Contributed Indexing :
Keywords: PI3K/Akt/mTOR pathway; apoptosis; erianin; in vivo and vitro; lung cancer
Entry Date(s) :
Date Created: 20210708 Latest Revision: 20210816
Update Code :
20210914
DOI :
10.1002/ptr.7154
PMID :
34236105
Czasopismo naukowe
Erianin is a small-molecule compound that is isolated from Dendrobium chrysotoxum Lindl. In recent years, it has been found to have evident antitumor activity in various cancers, such as bladder cancer, cervical cancer, and nasopharyngeal carcinoma. In this study, we assessed the effect of erianin on lung cancer in terms of cell growth inhibition and the related mechanism. First, erianin at a concentration of less than 1 nmol/L exhibited cytotoxicity in H1975, A549, LLC lung cancer cells, did not cause marked growth inhibition in normal lung and kidney cells, induced obvious apoptosis and G2/M phase arrest of cells, and inhibited the migration and invasion of lung cancer cells in vitro. Second, in a mouse xenograft model of lewis lung cancer (LLC), oral administration of erianin (50, 35, and 10 mg kg -1  day -1 for 12 days) substantially inhibited nodule growth, reduced the fluorescence counts of lewis cells and the percentage vascularity of tumor tissues, increased the number of apoptotic tumor cells, the thymus indices, up-regulated the levels of interleukin (IL)-2 and tumor necrosis factor-α (TNF-α), decreased IL-10 levels and the spleen index, and enhanced immune function. Lastly, the possible targets of erianin were determined by molecular docking and verified via western blot assay. The results indicated that erianin may achieve the above effects via inhibiting the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway in vitro and vivo. Taken together, the results showed that erianin had obvious antitumor effects via inhibiting the PI3K/Akt/mTOR pathway in vitro and vivo and may have potential clinical value for the treatment of lung cancer.
(© 2021 John Wiley & Sons Ltd.)

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