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Tytuł:
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[Cutaneous complications following hematopoietic stem cell transplantation].
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Autorzy:
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Araqi Houssaini L; CHU Ibn Rochd, service de dermatologie et de vénérologie, 1, rue des Hôpitaux, Casablanca, Maroc. Electronic address: lamiae_.
Hali F; CHU Ibn Rochd, service de dermatologie et de vénérologie, 1, rue des Hôpitaux, Casablanca, Maroc.
Quessar A; Hôpital 20 Août, service d'hématologie, 6, rue Lahcen Al Aarjoune, Casablanca, Maroc.
Marnissi F; CHU Ibn Rochd, service d'anatomie pathologique, 1, rue des Hôpitaux, Casablanca, Maroc.
Chiheb S; CHU Ibn Rochd, service de dermatologie et de vénérologie, 1, rue des Hôpitaux, Casablanca, Maroc.
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Transliterated Title:
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Complications cutanées post-allogreffe de cellules souches hématopoïétiques.
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Źródło:
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Bulletin du cancer [Bull Cancer] 2021 Sep; Vol. 108 (9), pp. 877-885. Date of Electronic Publication: 2021 Jul 08.
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Typ publikacji:
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Journal Article
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Język:
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French
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Imprint Name(s):
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Publication: Jan. 2015- : Paris : Elsevier
Original Publication: Paris : Masson
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MeSH Terms:
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Hematologic Diseases/*therapy
Hematopoietic Stem Cell Transplantation/*adverse effects
Skin Diseases/*etiology
Acute Disease ; Adolescent ; Adult ; Allografts ; Busulfan/therapeutic use ; Candidiasis/diagnosis ; Chickenpox/diagnosis ; Child ; Chronic Disease ; Dermatomycoses/diagnosis ; Dermatomycoses/microbiology ; Female ; Graft vs Host Disease/diagnosis ; Herpes Genitalis/diagnosis ; Humans ; Induction Chemotherapy/methods ; Malassezia ; Male ; Melphalan/therapeutic use ; Middle Aged ; Morocco ; Prospective Studies ; Skin Diseases/pathology ; Skin Diseases, Infectious/diagnosis ; Vidarabine/analogs & derivatives ; Vidarabine/therapeutic use ; Young Adult
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Contributed Indexing:
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Keywords: Allogreffe de cellules souches hématopoïétiques; Complications cutanées; Cutaneous complications; Graft versus host reaction; Hematopoietic stem cell allograft; Réactions de greffon contre l’hôte
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Substance Nomenclature:
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FA2DM6879K (Vidarabine)
G1LN9045DK (Busulfan)
P2K93U8740 (fludarabine)
Q41OR9510P (Melphalan)
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Entry Date(s):
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Date Created: 20210711 Date Completed: 20210922 Latest Revision: 20210922
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Update Code:
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20240105
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DOI:
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10.1016/j.bulcan.2021.03.015
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PMID:
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34246455
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Background: Hematopoietic stem cell allograft is a treatment for patients with severe constitutional or acquired hematopoietic system diseases. This act is always linked to complications requiring multidisciplinary care. Our study describes the post-allograft cutaneous complications.
Methods: A prospective study was conducted at the Hematology department of "20 Août Hospital" in Casablanca during a period going from January 2018 to December 2020; including all patients who presented acute or chronic cutaneous complications post-allograft.
Results: Twenty-five patients were included. All patients received induction chemotherapy (Busulfan/Fludarabine or Busulfan/Melphalan). A skin infection was found in 8 patients : four cases of Malassezia folliculitis, one case of perineal zona, one case of genital herpes, one case of varicella and one case of Candida sepsis. The acute graft versus host reaction was found in 3 patients, revealed by an erythematous rash all over the body. The chronic graft versus host reaction was found in five patients on a lichenoid form. Nine patients had a hyperpigmentation of the folds followed by detachment in the same areas, concluding to a Busulfan toxidermy.
Discussion: Hematopoietic stem cell allograft has many complications. The literature mainly specifies hematological and digestive complications, while skin complications are little described. Our series is special by reporting different types and mechanisms of skin complications that can occur; with a predominance of skin graft-on-host reactions and infections. It also reports an unusual Busulfan toxidermy.
(Copyright © 2021 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)
