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Tytuł:
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Alternaria Mycotoxins: An Overview of Toxicity, Metabolism, and Analysis in Food.
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Autorzy:
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Chen A; College of Life Science, Yantai University, Yantai, Shandong 264005, People's Republic of China.
Mao X; College of Life Science, Yantai University, Yantai, Shandong 264005, People's Republic of China.
Sun Q; College of Life Science, Yantai University, Yantai, Shandong 264005, People's Republic of China.
Wei Z; College of Life Science, Yantai University, Yantai, Shandong 264005, People's Republic of China.
Li J; Department of Chemical and Biochemical Engineering, University of Western Ontario, London, Ontario N6A 5B9, Canada.
You Y; College of Life Science, Yantai University, Yantai, Shandong 264005, People's Republic of China.
Zhao J; College of Life Science, Yantai University, Yantai, Shandong 264005, People's Republic of China.
Jiang G; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People's Republic of China.
Wu Y; NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100017, People's Republic of China.
Wang L; College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China.
Li Y; College of Life Science, Yantai University, Yantai, Shandong 264005, People's Republic of China.
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Źródło:
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Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Jul 21; Vol. 69 (28), pp. 7817-7830. Date of Electronic Publication: 2021 Jul 12.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Washington, American Chemical Society.
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MeSH Terms:
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Mycotoxins*/analysis
Mycotoxins*/toxicity
Alternaria ; Food ; Food Contamination/analysis
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Contributed Indexing:
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Keywords: Alternaria mycotoxins; analytical method; food; metabolic mechanism; toxicity
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Substance Nomenclature:
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0 (Mycotoxins)
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Entry Date(s):
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Date Created: 20210712 Date Completed: 20210722 Latest Revision: 20210722
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Update Code:
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20240105
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DOI:
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10.1021/acs.jafc.1c03007
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PMID:
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34250809
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The genus Alternaria is widely distributed in the environment. Numerous species of the genus Alternaria can produce a variety of toxic secondary metabolites, called Alternaria mycotoxins. In this review, natural occurrence, toxicity, metabolism, and analytical methods are introduced. The contamination of these toxins in foodstuffs is ubiquitous, and most of these metabolites present genotoxic and cytotoxic effects. Moreover, Alternaria toxins are mainly hydroxylated to catechol metabolites and combined with sulfate and glucuronic acid in in vitro arrays. A more detailed summary of the metabolism of Alternaria toxins is presented in this work. To effectively detect and determine the mycotoxins in food, analytical methods with high sensitivity and good accuracy are also reviewed. This review will guide the formulation of maximum residue limit standards in the future, covering both toxicity and metabolic mechanism of Alternaria toxins.
