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Tytuł:
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Air Pollution, Genetic Factors, and the Risk of Lung Cancer: A Prospective Study in the UK Biobank.
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Autorzy:
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Huang Y; Department of Epidemiology, Center for Global Health, School of Public Health, and.
Zhu M; Department of Epidemiology, Center for Global Health, School of Public Health, and.; Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China.; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Ji M; Department of Epidemiology, Center for Global Health, School of Public Health, and.
Fan J; Department of Epidemiology, Center for Global Health, School of Public Health, and.
Xie J; Department of Epidemiology, Center for Global Health, School of Public Health, and.
Wei X; Department of Epidemiology, Center for Global Health, School of Public Health, and.
Jiang X; Department of Epidemiology, Center for Global Health, School of Public Health, and.
Xu J; Department of Thoracic Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China; and.
Chen L; Department of Thoracic Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China; and.
Yin R; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Wang Y; Department of Epidemiology, Center for Global Health, School of Public Health, and.; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Dai J; Department of Epidemiology, Center for Global Health, School of Public Health, and.; Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China.
Jin G; Department of Epidemiology, Center for Global Health, School of Public Health, and.; Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China.
Xu L; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Hu Z; Department of Epidemiology, Center for Global Health, School of Public Health, and.; Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China.
Ma H; Department of Epidemiology, Center for Global Health, School of Public Health, and.; Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China.
Shen H; Department of Epidemiology, Center for Global Health, School of Public Health, and.; Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China.; Research Units of Cohort Study on Cardiovascular Diseases and Cancers, Chinese Academy of Medical Sciences, Beijing, China.
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Źródło:
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American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Oct 01; Vol. 204 (7), pp. 817-825.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2000- : New York, NY : American Thoracic Society
Original Publication: New York, NY : American Lung Association, c1994-
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MeSH Terms:
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Gene-Environment Interaction*
Genetic Predisposition to Disease*
Air Pollutants/*toxicity
Air Pollution/*adverse effects
Environmental Exposure/*adverse effects
Lung Neoplasms/*etiology
Particulate Matter/*toxicity
Adult ; Aged ; Air Pollutants/analysis ; Air Pollution/analysis ; Air Pollution/statistics & numerical data ; Biological Specimen Banks ; Environmental Exposure/analysis ; Environmental Exposure/statistics & numerical data ; Female ; Follow-Up Studies ; Humans ; Lung Neoplasms/epidemiology ; Male ; Middle Aged ; Nitrogen Oxides/toxicity ; Particulate Matter/analysis ; Polymorphism, Single Nucleotide ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; United Kingdom/epidemiology
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Grant Information:
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MC_PC_17228 United Kingdom MRC_ Medical Research Council; MC_QA137853 United Kingdom MRC_ Medical Research Council
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Contributed Indexing:
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Keywords: additive interaction; air pollution; genetic susceptibility; lung cancer
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Substance Nomenclature:
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0 (Air Pollutants)
0 (Nitrogen Oxides)
0 (Particulate Matter)
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Entry Date(s):
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Date Created: 20210712 Date Completed: 20211013 Latest Revision: 20220720
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Update Code:
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20240105
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DOI:
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10.1164/rccm.202011-4063OC
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PMID:
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34252012
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Rationale: Both genetic and environmental factors contribute to lung cancer, but the degree to which air pollution modifies the impact of genetic susceptibility on lung cancer remains unknown. Objectives: To investigate whether air pollution and genetic factors jointly contribute to incident lung cancer. Methods: We analyzed data from 455,974 participants (53% women) without previous cancer at baseline in the UK Biobank. The concentrations of particulate matter (PM) (PM ⩽2.5 μm in aerodynamic diameter [PM 2.5 ], coarse PM between 2.5 μm and 10 μm in aerodynamic diameter [PM coarse ], and PM ⩽10 μm in aerodynamic diameter [PM 10 ]), nitrogen dioxide (NO 2 ), and nitrogen oxides (NO x ) were estimated by using land-use regression models, and the association between air pollutants and incident lung cancer was investigated by using a Cox proportional hazard model. Furthermore, we constructed a polygenic risk score and evaluated whether air pollutants modified the effect of genetic susceptibility on the development of lung cancer. Measurements and Main Results: The results showed significant associations between the risk of lung cancer and PM 2.5 (hazard ratio [HR], 1.63; 95% confidence interval [CI], 1.33-2.01; per 5 μg/m 3 ), PM 10 (HR, 1.53; 95% CI, 1.20-1.96; per 10 μg/m 3 ), NO 2 (HR, 1.10; 95% CI, 1.05-1.15; per 10 μg/m 3 ), and NO x (HR, 1.13; 95% CI, 1.07-1.18; per 20 μg/m 3 ). There were additive interactions between air pollutants and the genetic risk. Compared with participants with low genetic risk and low air pollution exposure, those with high air pollution exposure and high genetic risk had the highest risk of lung cancer (PM 2.5 : HR, 1.71; 95% CI, 1.45-2.02; PM 10 : HR, 1.77; 95% CI, 1.50-2.10; NO 2 : HR, 1.77; 95% CI, 1.42-2.22; NO x : HR, 1.67; 95% CI, 1.43-1.95). Conclusions: Long-term exposure to air pollution may increase the risk of lung cancer, especially in those with high genetic risk.
Comment in: Am J Respir Crit Care Med. 2021 Oct 1;204(7):752-753. (PMID: 34370960)
Comment in: Am J Respir Crit Care Med. 2022 Feb 1;205(3):367. (PMID: 34788195)
Comment in: Am J Respir Crit Care Med. 2022 Feb 1;205(3):367-368. (PMID: 34788204)
Comment in: Am J Respir Crit Care Med. 2022 Jun 15;205(12):1486-1487. (PMID: 35465852)
Comment in: Am J Respir Crit Care Med. 2022 Jun 15;205(12):1487-1489. (PMID: 35465853)
Erratum in: Am J Respir Crit Care Med. 2022 May 15;205(10):1254. (PMID: 35549852)
