Isolation of a novel insect-specific flavivirus with immunomodulatory effects in vertebrate systems.

Szczegóły
Abstrakt

Tytuł:: Isolation of a novel insect-specific flavivirus with immunomodulatory effects in vertebrate systems.
Autorzy:: Auguste AJ; Department of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA. Electronic address: .
Langsjoen RM; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Porier DL; Department of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.
Erasmus JH; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Bergren NA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Bolling BG; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Luo H; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Singh A; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Guzman H; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Popov VL; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Travassos da Rosa APA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Wang T; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Kang L; Edward Via College of Osteopathic Medicine, Monroe, LA, 71203, USA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24060, USA.
Allen IC; Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24060, USA.
Carrington CVF; Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Tesh RB; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Weaver SC; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Źródło:: Virology [Virology] 2021 Oct; Vol. 562, pp. 50-62. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Original Publication: New York, Academic Press.
MeSH Terms:: Immunomodulation*
Flavivirus/*immunology
Insect Viruses/*immunology
Vertebrates/*immunology
Animals ; Antigens, Viral/immunology ; Cross Reactions ; Culicidae/virology ; Disease Models, Animal ; Flavivirus/genetics ; Flavivirus/isolation & purification ; Flavivirus/pathogenicity ; Genome, Viral/genetics ; Host Specificity ; Immunity, Innate ; Insect Viruses/genetics ; Insect Viruses/isolation & purification ; Insect Viruses/pathogenicity ; Macrophages/immunology ; Mice ; Phylogeny ; Vertebrates/virology ; Viral Interference ; Virus Replication ; West Nile Fever/immunology ; West Nile virus/immunology ; West Nile virus/pathogenicity
References:: Nat Med. 2004 Dec;10(12):1366-73. (PMID: 15558055)
Electrophoresis. 1997 Dec;18(15):2714-23. (PMID: 9504803)
Acta Virol. 2004;48(3):135-43. (PMID: 15595206)
PLoS One. 2013;8(2):e56534. (PMID: 23460804)
Cad Saude Publica. 2012 Feb;28(2):229-38. (PMID: 22331150)
Vaccines (Basel). 2020 Sep 02;8(3):. (PMID: 32887302)
J Virol. 2013 Jan;87(2):818-28. (PMID: 23115296)
Genome Res. 2009 Jun;19(6):1117-23. (PMID: 19251739)
Am J Trop Med Hyg. 2006 Nov;75(5):986-93. (PMID: 17124001)
Sci Rep. 2017 Jun 7;7(1):2940. (PMID: 28592864)
Virus Genes. 2013 Dec;47(3):532-45. (PMID: 23877720)
Sci Rep. 2018 Jul 18;8(1):10889. (PMID: 30022130)
J Med Entomol. 2008 Nov;45(6):1187-90. (PMID: 19058647)
Bioinformatics. 2009 Jul 15;25(14):1754-60. (PMID: 19451168)
J Med Entomol. 2011 Sep;48(5):1031-8. (PMID: 21936322)
Am J Trop Med Hyg. 2010 Dec;83(6):1262-5. (PMID: 21118932)
J Gen Virol. 1978 Sep;40(3):531-44. (PMID: 690610)
J Gen Virol. 2006 Apr;87(Pt 4):735-748. (PMID: 16528021)
J Virol. 2009 May;83(9):4462-8. (PMID: 19224998)
Virology. 2009 Sep 15;392(1):123-30. (PMID: 19631956)
Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W70-4. (PMID: 18424795)
Virology. 2012 Nov 25;433(2):471-8. (PMID: 22999256)
J Gen Virol. 2012 Feb;93(Pt 2):223-234. (PMID: 22012464)
Mol Biol Evol. 2008 Jul;25(7):1253-6. (PMID: 18397919)
J Am Mosq Control Assoc. 2006 Mar;22(1):70-5. (PMID: 16646325)
J Exp Med. 2006 Feb 20;203(2):413-24. (PMID: 16461338)
Arch Virol. 2011 Jul;156(7):1263-7. (PMID: 21409444)
Am J Trop Med Hyg. 2009 Jan;80(1):85-95. (PMID: 19141845)
Virology. 2012 Jun 5;427(2):90-7. (PMID: 22425062)
Arch Virol. 2003 Jun;148(6):1085-93. (PMID: 12756616)
Vector Borne Zoonotic Dis. 2012 Mar;12(3):223-9. (PMID: 22022811)
Infect Genet Evol. 2013 Oct;19:188-94. (PMID: 23871775)
J Virol. 2012 Feb;86(4):2337-46. (PMID: 22156523)
J Virol. 2006 Nov;80(22):11000-8. (PMID: 16943291)
J Gen Virol. 2009 Nov;90(Pt 11):2669-2678. (PMID: 19656970)
Virology. 2009 Mar 30;386(1):154-9. (PMID: 19193389)
Nucleic Acids Res. 2003 Jul 1;31(13):3406-15. (PMID: 12824337)
J Med Virol. 2004 Apr;72(4):618-24. (PMID: 14981764)
J Gen Virol. 2013 Jun;94(Pt 6):1266-1272. (PMID: 23515021)
J Insect Sci. 2007;7:1-7. (PMID: 20337552)
Bioinformatics. 2010 Jan 1;26(1):139-40. (PMID: 19910308)
Virology. 2021 Jul;559:30-39. (PMID: 33812340)
Bing Du Xue Bao. 2012 Sep;28(5):511-6. (PMID: 23233925)
Virology. 2009 Aug 15;391(1):119-29. (PMID: 19580982)
Sci Rep. 2019 Dec 31;9(1):20399. (PMID: 31892710)
J Virol. 2015 Jan 15;89(2):1404-18. (PMID: 25392227)
Nat Methods. 2012 Mar 04;9(4):357-9. (PMID: 22388286)
PLoS One. 2009 Jul 20;4(7):e6282. (PMID: 19617912)
Virology. 2007 Mar 15;359(2):405-14. (PMID: 17070886)
Bioinformatics. 2006 Jan 15;22(2):195-201. (PMID: 16301204)
Virus Res. 2012 Aug;167(2):152-61. (PMID: 22579596)
Virology. 2013 Jun 5;440(2):134-9. (PMID: 23582303)
J Am Mosq Control Assoc. 1999 Sep;15(3):295-8. (PMID: 10480118)
J Infect Dis. 1998 Mar;177(3):774-8. (PMID: 9498462)
J Gen Virol. 2014 Dec;95(Pt 12):2796-2808. (PMID: 25146007)
Parasit Vectors. 2012 Dec 14;5:293. (PMID: 23241081)
J Virol. 2018 Jan 30;92(4):. (PMID: 29187545)
J Virol. 2009 Sep;83(18):9532-40. (PMID: 19570865)
J Med Entomol. 2009 Nov;46(6):1474-82. (PMID: 19960700)
Vaccines (Basel). 2020 May 29;8(2):. (PMID: 32485930)
Lancet. 2008 Feb 9;371(9611):500-9. (PMID: 18262042)
Am J Trop Med Hyg. 2011 Jul;85(1):162-8. (PMID: 21734143)
Nat Biotechnol. 2011 Jan;29(1):24-6. (PMID: 21221095)
Nat Struct Mol Biol. 2013 Jan;20(1):105-10. (PMID: 23241927)
mSphere. 2017 Jan 11;2(1):. (PMID: 28101536)
Biotechniques. 2000 Jun;28(6):1102, 1104. (PMID: 10868275)
Virology. 2015 Dec;486:272-83. (PMID: 26519596)
Virology. 2013 Jan 20;435(2):220-4. (PMID: 23127596)
J Virol. 2012 Jun;86(11):6084-96. (PMID: 22457519)
Sci Transl Med. 2019 Dec 11;11(522):. (PMID: 31826984)
J Med Entomol. 2000 Nov;37(6):835-9. (PMID: 11126537)
Nat Med. 2017 Feb;23(2):192-199. (PMID: 27991917)
Arch Virol. 2003 Jun;148(6):1095-118. (PMID: 12756617)
PLoS One. 2012;7(6):e39387. (PMID: 22724010)
J Gen Virol. 1996 Oct;77 ( Pt 10):2541-5. (PMID: 8887488)
mSphere. 2017 Jul 12;2(4):. (PMID: 28713857)
J Virol. 2015 Jan;89(1):676-87. (PMID: 25355879)
J Med Entomol. 2010 Jul;47(4):625-33. (PMID: 20695278)
Emerg Microbes Infect. 2021 Dec;10(1):305-316. (PMID: 33539255)
PLoS Negl Trop Dis. 2015 Oct 22;9(10):e0004119. (PMID: 26492074)
Grant Information:: K22 AI125474 United States AI NIAID NIH HHS; R01 AI121452 United States AI NIAID NIH HHS; R01 AI153433 United States AI NIAID NIH HHS; R24 AI120942 United States AI NIAID NIH HHS
Contributed Indexing:: Keywords: Aripo virus; Flavivirus infection; Flavivirus pathogenesis; Insect-specific flavivirus; Super-infection exclusion; West nile virus
Substance Nomenclature:: 0 (Antigens, Viral)
Entry Date(s):: Date Created: 20210713 Date Completed: 20220104 Latest Revision: 20221003
Update Code:: 20240105
PubMed Central ID:: PMC8419152
DOI:: 10.1016/j.virol.2021.07.004
PMID:: 34256244
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We describe the isolation and characterization of a novel insect-specific flavivirus (ISFV), tentatively named Aripo virus (ARPV), that was isolated from Psorophora albipes mosquitoes collected in Trinidad. The ARPV genome was determined and phylogenetic analyses showed that it is a dual host associated ISFV, and clusters with the main mosquito-borne flaviviruses. ARPV antigen was significantly cross-reactive with Japanese encephalitis virus serogroup antisera, with significant cross-reactivity to Ilheus and West Nile virus (WNV). Results suggest that ARPV replication is limited to mosquitoes, as it did not replicate in the sandfly, culicoides or vertebrate cell lines tested. We also demonstrated that ARPV is endocytosed into vertebrate cells and is highly immunomodulatory, producing a robust innate immune response despite its inability to replicate in vertebrate systems. We show that prior infection or coinfection with ARPV limits WNV-induced disease in mouse models, likely the result of a robust ARPV-induced type I interferon response.
(Published by Elsevier Inc.)

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