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Tytuł:
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Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity?
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Autorzy:
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Aguiar SS; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.; Physical Education Department, University Center - UDF, DF, Brazil.
Rosa TS; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.
Neves RVP; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.
Leite PLA; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.
Maciel LA; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.
Gutierrez SD; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.
Rosa EC; Graduate Program in Health Sciences, Laboratory of Molecular Pharmacology, University of Brasilia, Federal District, Brazil.
Andrade RV; Graduate Program in Biotechnology, Catholic University of Brasília, Federal District, Brazil.
Degens H; Department of Life Sciences, Research Centre for Musculoskeletal Science & Sports Medicine, Manchester Metropolitan University.; Lithuanian Sports University, Kaunas.
Korhonen MT; Faculty of Sport and Health Sciences, Gerontology Research Center, University of Jyvaskyla, Finland.
Lewis JE; Departments of Psychiatry and Behavioral Sciences and Psychology, University of Miami, Coral Gables Florida, United States.
Simões HG; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.
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Źródło:
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International journal of sports medicine [Int J Sports Med] 2022 Jan; Vol. 43 (1), pp. 29-33. Date of Electronic Publication: 2021 Jul 13.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Stuttgart : Thieme
Original Publication: Stuttgart, New York, Thieme.
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MeSH Terms:
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Athletes*
Longevity*
Sirtuin 1*/genetics
Insulin/*blood
Telomere/*ultrastructure
Adult ; Aging ; Cross-Sectional Studies ; Humans ; Leukocytes ; Male ; Middle Aged
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Grant Information:
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Fundação de Apoio à Pesquisa do Distrito Federal (FAP/DF) 0193.001762/2017
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Substance Nomenclature:
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0 (Insulin)
EC 3.5.1.- (SIRT1 protein, human)
EC 3.5.1.- (Sirtuin 1)
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Entry Date(s):
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Date Created: 20210713 Date Completed: 20220106 Latest Revision: 20220106
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Update Code:
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20240105
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DOI:
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10.1055/a-1510-9259
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PMID:
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34256387
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Lower SIRT1 and insulin resistance are associated with accelerated telomere shortening. This study investigated whether the lifestyle of master athletes can attenuate these age-related changes and thereby slow aging. We compared insulin, SIRT1, and telomere length in highly trained male master athletes (n=52; aged 49.9±7.2 yrs) and age-matched non-athletes (n=19; aged 47.3±8.9 yrs). This is a cross-sectional study, in which all data were collected in one visit. Overnight fasted SIRT1 and insulin levels in whole blood were assessed using commercial kits. Relative telomere length was determined in leukocytes through qPCR analyses. Master athletes had higher SIRT1, lower insulin, and longer telomere length than age-matched non-athletes ( p <0.05 for all). Insulin was inversely associated with SIRT1 ( r =-0.38; p =0.001). Telomere length correlated positively with SIRT1 ( r =0.65; p =0.001), whereas telomere length and insulin were not correlated ( r =0.03; p =0.87). In conclusion, master athletes have higher SIRT1, lower insulin, and longer telomeres than age-matched non-athletes. Furthermore, SIRT1 was negatively associated with insulin and positively associated with telomere length. These findings suggest that in this sample of middle-aged participants reduced insulin, increased SIRT1 activity, and attenuation of biological aging are connected.
Competing Interests: The authors declare that they have no conflict of interest.
(Thieme. All rights reserved.)
