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Tytuł:
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Prenatal air pollution exposure to diesel exhaust induces cardiometabolic disorders in adulthood in a sex-specific manner.
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Autorzy:
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Rousseau-Ralliard D; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France; Ecole Nationale Vétérinaire d'Alfort, BREED, 94700, Maisons-Alfort, France. Electronic address: .
Richard C; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France; MIMA2 Platform, INRAE, 78350, Jouy-en-Josas, France.
Hoarau P; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France.
Lallemand MS; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France.
Morillon L; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France.
Aubrière MC; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France; Ecole Nationale Vétérinaire d'Alfort, BREED, 94700, Maisons-Alfort, France.
Valentino SA; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France; Ecole Nationale Vétérinaire d'Alfort, BREED, 94700, Maisons-Alfort, France.
Dahirel M; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France; Ecole Nationale Vétérinaire d'Alfort, BREED, 94700, Maisons-Alfort, France.
Guinot M; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France.
Fournier N; Lip(Sys)2 - EA 7357, Athérosclérose et macrophages: impact des phospholipides et des fonctions mitochondriales sur l'efflux du cholestérol, Université Paris Saclay, UFR de Pharmacie, 92290, Châtenay-Malabry, France; Laboratoire de Biochimie, AP-HP (Assistance Publique-Hôpitaux de Paris), Hôpital Européen Georges Pompidou, 75015, Paris, France.
Morin G; Université Paris-Saclay, INRAE, UE SAAJ, 78350, Jouy en Josas, France.
Mourier E; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France.
Camous S; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France.
Slama R; Inserm and Univ. Grenoble Alpes, U823, IAB Research Center, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, 38700, Grenoble, France.
Cassee FR; Centre for Sustainability, Environment and Health, National Institute for Public Health and the Environment, Bilthoven, Netherlands; Institute of Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
Couturier-Tarrade A; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France; Ecole Nationale Vétérinaire d'Alfort, BREED, 94700, Maisons-Alfort, France.
Chavatte-Palmer P; Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France; Ecole Nationale Vétérinaire d'Alfort, BREED, 94700, Maisons-Alfort, France; MIMA2 Platform, INRAE, 78350, Jouy-en-Josas, France.
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Źródło:
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Environmental research [Environ Res] 2021 Sep; Vol. 200, pp. 111690. Date of Electronic Publication: 2021 Jul 14.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: <2000- > : Amsterdam : Elsevier
Original Publication: New York, Academic Press.
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MeSH Terms:
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Air Pollution*
Cardiovascular Diseases*/chemically induced
Cardiovascular Diseases*/epidemiology
Prenatal Exposure Delayed Effects*/chemically induced
Adult ; Animals ; Female ; Humans ; Male ; Maternal Exposure/adverse effects ; Pregnancy ; Rabbits ; Vehicle Emissions/toxicity
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Grant Information:
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311765 International ERC_ European Research Council
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Contributed Indexing:
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Keywords: Adult offspring; Fetal programming; Gestational exposure; Intergenerational effect; Rabbit biomedical model
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Substance Nomenclature:
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0 (Vehicle Emissions)
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Entry Date(s):
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Date Created: 20210717 Date Completed: 20210906 Latest Revision: 20210929
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Update Code:
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20240105
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DOI:
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10.1016/j.envres.2021.111690
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PMID:
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34273365
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Background: Results from observational and experimental studies indicate that exposure to air pollutants during gestation reduces birth weight, whereas little is known on potential cardiometabolic consequences for the offspring at adulthood.
Objectives: Our aim was to evaluate the long-term effects of gestational exposure to diesel engine exhaust (DE) on adult offspring phenotype in a rabbit model.
Methods: The protocol was designed to mimic human exposure in large European cities. Females rabbits were exposed to diluted (1 mg/m 3 ) DE (exposed, n = 9) or clean air (controls, n = 7), from 3 days after mating, 2 h/d and 5 d/wk in a nose-only inhalation system throughout gestation (gestation days 3-27). After birth and weaning, 72 offspring (47 exposed and 25 controls) were raised until adulthood (7.5 months) to evaluate their cardio-metabolic status, including the monitoring of body weight and food intake, fasting biochemistry, body composition (iDXA), cardiovascular parameters and glucose tolerance. After a metabolic challenge (high fat diet in males and gestation in females), animals were euthanized for postmortem phenotyping.
Results: Sex-specific responses to maternal exposure were observed in adult offspring. Age-related increases in blood pressure (p = 0.058), glycaemia (p = 0.029), and perirenal fat mass (p = 0.026) as well as reductions in HDL-cholesterol (p = 0.025) and fat-to-body weight ratio (p = 0.011) were observed in exposed males, suggesting a metabolic syndrome. Almost only trends were observed in exposed females with higher triglycerides and decreased bone density compared to control females. Metabolic challenges triggered or amplified some biological responses, especially in females.
Conclusions: In utero exposure to air pollution predisposed rabbit offspring to cardiometabolic disorders in a sex-specific manner.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
