The Fruits of Paris polyphylla Inhibit Colorectal Cancer Cell Migration Induced by Fusobacterium nucleatum -Derived Extracellular Vesicles.

Tytuł:: The Fruits of Paris polyphylla Inhibit Colorectal Cancer Cell Migration Induced by Fusobacterium nucleatum -Derived Extracellular Vesicles.
Autorzy:: Lin LT; Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.
Shi YC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.
Choong CY; Department of Chinese Medicine, Taipei University Hospital, Taipei 110301, Taiwan.
Tai CJ; Department of Chinese Medicine, Taipei University Hospital, Taipei 110301, Taiwan.; Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 110301, Taiwan.; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Jul 04; Vol. 26 (13). Date of Electronic Publication: 2021 Jul 04.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, c1995-
MeSH Terms:: Cell Movement*
Colorectal Neoplasms/*drug therapy
Extracellular Vesicles/*microbiology
Fruit/*chemistry
Fusobacterium nucleatum/*physiology
Liliaceae/*chemistry
Plant Extracts/*pharmacology
Carcinogenesis ; Cell Proliferation ; Colorectal Neoplasms/microbiology ; Colorectal Neoplasms/pathology ; Humans ; Tumor Cells, Cultured
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Contributed Indexing:: Keywords: Fusobacterium nucleatum; Paris polyphylla; cell migration; complementary medicine; extracellular vesicles
Substance Nomenclature:: 0 (Plant Extracts)
Entry Date(s):: Date Created: 20210719 Date Completed: 20210913 Latest Revision: 20210913
Update Code:: 20240105
PubMed Central ID:: PMC8271733
DOI:: 10.3390/molecules26134081
PMID:: 34279421
: Czasopismo naukowe

Pełny tekst

Colorectal cancer (CRC) is one of the most common cancers worldwide. Gut microbiota are highly associated with CRC, and Fusobacterium nucleatum was found to be enriched in CRC lesions and correlated with CRC carcinogenesis and metastases. Paris polyphylla is a well-known herbal medicine that showed anticancer activity. The present study demonstrates that P. polyphylla inhibited the growth of CRC cells. In addition, treating with active compounds pennogenin 3- O -beta-chacotrioside and polyphyllin VI isolated from P. polyphylla inhibited the growth of F. nucleatum . We also found that extracellular vesicles (EVs) released from F. nucleatum could promote mitochondrial fusion and cell invasion in CRC cells, whereas active components from P. polyphylla could dampen such an impact. The data suggest that P. polyphylla and its active ingredients could be further explored as potential candidates for developing complementary chemotherapy for the treatment of CRC.

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