Association between ACTN3 R577X genotype and risk of non-contact injury in trained athletes: A systematic review.

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Tytuł:: Association between ACTN3 R577X genotype and risk of non-contact injury in trained athletes: A systematic review.
Autorzy:: Zouhal H; M2S (Laboratoire Mouvement, Sport, Santé)-EA 1274, Department of Sport Sciences, University of Rennes, Rennes F-35000, France. Electronic address: .
Coso JD; Rey Juan Carlos University, Centre for Sport Studies, Madrid 28032, Spain.
Jayavel A; SRM College of Physiotherapy, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur 603203, India.
Tourny C; Department of Sport Sciences, University of Rouen, Mont Saint Aignan, CETAPS EA 3832, F-76821, France.
Ravé G; Toulouse Football Club, Toulouse 31000, France.
Jebabli N; Higher Institute of Sport and Physical Education, Ksar-Said, University of Manouba, Tunis 2010, Tunisia.
Clark CCT; Centre for Intelligent Healthcare, Coventry University, Coventry CV1 5FB, UK.
Barthélémy B; Toulouse Football Club, Toulouse 31000, France.
Hackney AC; Department of Exercise & Sport Science, Department of Nutrition, University of North Carolina, Chapel Hill, NC 27514, USA.
Abderrahman AB; Higher Institute of Sport and Physical Education, Ksar-Said, University of Manouba, Tunis 2010, Tunisia.
Źródło:: Journal of sport and health science [J Sport Health Sci] 2023 May; Vol. 12 (3), pp. 359-368. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji:: Systematic Review; Journal Article; Review
Język:: English
Imprint Name(s):: Original Publication: [Shanghai] : Shanghai University of Sport, c2012-
MeSH Terms:: Polymorphism, Genetic*
Exercise*
Male ; Humans ; Female ; Genotype ; Spain ; Athletes ; Actinin/genetics
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Contributed Indexing:: Keywords: Athletic performance; Exercise-related injury; Muscle injury; Single nucleotide polymorphism; α-actinin-3 deficiency
Substance Nomenclature:: 11003-00-2 (Actinin)
0 (ACTN3 protein, human)
Entry Date(s):: Date Created: 20210720 Date Completed: 20230517 Latest Revision: 20230601
Update Code:: 20240105
PubMed Central ID:: PMC10199131
DOI:: 10.1016/j.jshs.2021.07.003
PMID:: 34284153
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Purpose: The aim of this study was to review, systematically, evidence concerning the link between the ACTN3 R577X polymorphism and the rates and severity of non-contact injuries and exercise-induced muscle damage in athletes and individuals enrolled in exercise training programs.
Methods: A computerized literature search was performed in the electronic databases PubMed, Web of Science, and SPORTDiscus, from inception until November 2020. All included studies compared the epidemiological characteristics of non-contact injury between the different genotypes of the ACTN3 R577X polymorphism.
Results: Our search identified 492 records. After the screening of titles, abstracts, and full texts, 13 studies examining the association between the ACTN3 genotypes and the rate and severity of non-contact injury were included in the analysis. These studies were performed in 6 different countries (Spain, Japan, Brazil, China, the Republic of Korea, and Italy) and involved a total participant pool of 1093 participants. Of the studies, 2 studies involved only women, 5 studies involved only men, and 6 studies involved both men and women. All the studies included were classified as high-quality studies (≥6 points in the Physiotherapy Evidence Database (PEDro) scale score). Overall, evidence suggests there is an association between the ACTN3 R577X genotype and non-contact injury in 12 investigations. Six studies observed a significant association between ACTN3 R577X polymorphism and exercise induced muscle damage: 2 with non-contact ankle injury, 3 with non-contact muscle injury, and 1 with overall non-contact injury.
Conclusion: The present findings support the premise that possessing the ACTN3 XX genotype may predispose athletes to a higher probability of some non-contact injuries, such as muscle injury, ankle sprains, and higher levels of exercise-induced muscle damage.
Competing Interests: Competing interests The authors declare that they have no competing interests.
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