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Tytuł pozycji:

Association between ACTN3 R577X genotype and risk of non-contact injury in trained athletes: A systematic review.

Tytuł :
Association between ACTN3 R577X genotype and risk of non-contact injury in trained athletes: A systematic review.
Autorzy :
Zouhal H; M2S (Laboratoire Mouvement, Sport, Santé)-EA 1274, Department of Sport Sciences, University of Rennes, Rennes F-35000, France. Electronic address: .
Coso JD; Rey Juan Carlos University, Centre for Sport Studies, Madrid 28032, Spain.
Jayavel A; SRM College of Physiotherapy, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur 603203, India.
Tourny C; Department of Sport Sciences, University of Rouen, Mont Saint Aignan, CETAPS EA 3832, F-76821, France.
Ravé G; Toulouse Football Club, Toulouse 31000, France.
Jebabli N; Higher Institute of Sport and Physical Education, Ksar-Said, University of Manouba, Tunis 2010, Tunisia.
Clark CCT; Centre for Intelligent Healthcare, Coventry University, Coventry CV1 5FB, UK.
Barthélémy B; Toulouse Football Club, Toulouse 31000, France.
Hackney AC; Department of Exercise & Sport Science, Department of Nutrition, University of North Carolina, Chapel Hill, NC 27514, USA.
Abderrahman AB; Higher Institute of Sport and Physical Education, Ksar-Said, University of Manouba, Tunis 2010, Tunisia.
Pokaż więcej
Źródło :
Journal of sport and health science [J Sport Health Sci] 2021 Jul 17. Date of Electronic Publication: 2021 Jul 17.
Publication Model :
Ahead of Print
Typ publikacji :
Journal Article; Review
Język :
English
Imprint Name(s) :
Original Publication: [Shanghai] : Shanghai University of Sport, c2012-
Contributed Indexing :
Keywords: Athletic performance; Exercise-related injury; Muscle injury; Single nucleotide polymorphism; α-actinin-3 deficiency
Entry Date(s) :
Date Created: 20210720 Latest Revision: 20211021
Update Code :
20211105
DOI :
10.1016/j.jshs.2021.07.003
PMID :
34284153
Czasopismo naukowe
Background: The aim of this study was to review, systematically, evidence concerning the link between the ACTN3 R577X polymorphism and the rates and severity of non-contact injuries and exercise-induced muscle damage in athletes and individuals enrolled in exercise training programs.
Methods: A computerized literature search was performed in the electronic databases PubMed, Web of Science, and SPORTDiscus, from inception until November 2020. All included studies compared the epidemiological characteristics of non-contact injury between the different genotypes of the ACTN3 R577X polymorphism.
Results: Our search identified 492 records. After the screening of titles, abstracts, and full texts, 13 studies examining the association between the ACTN3 genotypes and the rate and severity of non-contact injury were included in the analysis. These studies were performed in 6 different countries (Spain, Japan, Brazil, China, Republic of Korea, and Italy) and involved a total participant pool of 1093 participants. Of the studies, 2 studies involved only women, 5 studies involved only men, and 6 studies involved both men and women. All the studies included were classified as high-quality studies (≥6 points in the Physiotherapy Evidence Database (PEDro) scale score). Overall, evidence suggests there is an association between the ACTN3 R577X genotype and non-contact injury in 12 investigations. Six studies observed a significant association between ACTN3 R577X polymorphism and exercise induced muscle damage: two with non-contact ankle injury, three with non-contact muscle injury, and one with overall non-contact injury.
Conclusion: The present findings support the premise that possessing the ACTN3 XX genotype may predispose athletes to a higher probability of some non-contact injuries, such as muscle injury, ankle sprains, and higher levels of exercise-induced muscle damage.
(Copyright © 2021. Production and hosting by Elsevier B.V.)

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