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Tytuł:
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Short-term dietary restriction maintains synaptic plasticity whereas short-term overfeeding alters cellular dynamics in the aged brain: evidence from the zebrafish model organism.
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Autorzy:
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Karoglu-Eravsar ET; Interdisciplinary Program in Neuroscience, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Turkey; National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, Turkey; Department of Molecular Biology and Genetics, Zebrafish Facility, Bilkent University, Ankara, Turkey; Department of Psychology, Selcuk University, Konya, Turkey.
Tuz-Sasik MU; Interdisciplinary Program in Neuroscience, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Turkey; National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, Turkey; Department of Molecular Biology and Genetics, Zebrafish Facility, Bilkent University, Ankara, Turkey.
Adams MM; Interdisciplinary Program in Neuroscience, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Turkey; National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, Turkey; Department of Molecular Biology and Genetics, Zebrafish Facility, Bilkent University, Ankara, Turkey; Department of Psychology, Bilkent University, Ankara, Turkey. Electronic address: .
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Źródło:
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Neurobiology of aging [Neurobiol Aging] 2021 Oct; Vol. 106, pp. 169-182. Date of Electronic Publication: 2021 Jun 19.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: New York : Elsevier
Original Publication: Fayetteville, N.Y. : Ankho International.
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MeSH Terms:
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Diet Therapy*
Aging/*pathology
Aging/*physiology
Brain/*cytology
Brain/*pathology
Cognitive Dysfunction/*etiology
Cognitive Dysfunction/*prevention & control
Energy Intake/*physiology
Feeding Behavior/*physiology
Hyperphagia/*complications
Hyperphagia/*physiopathology
Neuronal Plasticity/*physiology
Animals ; Disks Large Homolog 4 Protein/metabolism ; Doublecortin-Like Kinases/metabolism ; Healthy Aging ; Models, Animal ; Receptors, AMPA/metabolism ; Time Factors ; Zebrafish
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Contributed Indexing:
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Keywords: Aging; Dietary restriction; Overfeeding; Synapses; Zebrafish
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Substance Nomenclature:
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0 (Disks Large Homolog 4 Protein)
0 (Receptors, AMPA)
EC 2.7.1.11 (Doublecortin-Like Kinases)
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Entry Date(s):
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Date Created: 20210720 Date Completed: 20211231 Latest Revision: 20211231
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Update Code:
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20240105
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DOI:
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10.1016/j.neurobiolaging.2021.06.010
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PMID:
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34284260
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Increased caloric intake (OF) impairs quality of life causing comorbidities with other diseases and cognitive deficits, whereas dietary restriction (DR) increases healthspan by preventing age-related deteriorations. To understand the effects of these opposing dietary regimens on the cellular and synaptic dynamics during brain aging, the zebrafish model, which shows gradual aging like mammals, was utilized. Global changes in cellular and synaptic markers with respect to age and a 12 week dietary regimen of OF and DR demonstrated that aging reduces the levels of the glutamate receptor subunits, GLUR2/3, inhibitory synaptic clustering protein, GEP, synaptic vesicle protein, SYP, and early-differentiated neuronal marker, HuC. DR significantly elevates levels of glutamate receptor subunits, GLUR2/3, and NMDA clustering protein, PSD95, levels, while OF subtly increases the level of the neuronal protein, DCAMKL1. These data suggest that decreased caloric intake within the context of aging has more robust effects on synapses than cellular proteins, whereas OF alters cellular dynamics. Thus, patterns like these should be taken into account for possible translation to human subjects.
(Copyright © 2021. Published by Elsevier Inc.)