Developing a core outcome set for periodontal trials.

Tytuł:: Developing a core outcome set for periodontal trials.
Autorzy:: Lamont TJ; Dundee Dental School & Hospital, University of Dundee, Dundee, United Kingdom.
Clarkson JE; Dundee Dental School & Hospital, University of Dundee, Dundee, United Kingdom.
Ricketts DNJ; Dundee Dental School & Hospital, University of Dundee, Dundee, United Kingdom.
Heasman PA; Newcastle University School of Dental Sciences, Newcastle upon Tyne, United Kingdom.
Ramsay CR; Health Services Research Unit, University of Aberdeen, Aberdeen, United Kingdom.
Gillies K; Health Services Research Unit, University of Aberdeen, Aberdeen, United Kingdom.
Źródło:: PloS one [PLoS One] 2021 Jul 22; Vol. 16 (7), pp. e0254123. Date of Electronic Publication: 2021 Jul 22 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:: Delphi Technique*
Endpoint Determination*
Quality of Life*
Periodontal Diseases/*therapy
Clinical Trials as Topic ; Female ; Humans ; Male ; Periodontal Diseases/epidemiology
References:: Dent Traumatol. 2018 Feb;34(1):4-11. (PMID: 28873277)
Arch Dis Child. 2015 Apr;100(4):359-63. (PMID: 25414251)
J Clin Periodontol. 2017 Jun;44(6):601-602. (PMID: 28423193)
J Periodontol. 2013 Apr;84(4 Suppl):S8-S19. (PMID: 23631586)
Rheumatology (Oxford). 2003 Dec;42(12):1452-9. (PMID: 12832713)
J Clin Periodontol. 2013 Apr;40 Suppl 14:S24-9. (PMID: 23627332)
J Clin Periodontol. 2015 Apr;42 Suppl 16:S1-4. (PMID: 25683242)
J Clin Periodontol. 2013 Apr;40 Suppl 14:S51-69. (PMID: 23627334)
J Clin Periodontol. 2018 Feb;45(2):138-149. (PMID: 29280174)
J Clin Periodontol. 2015 May;42(5):407-12. (PMID: 25808877)
Trials. 2017 Jun 20;18(Suppl 3):280. (PMID: 28681707)
Trials. 2015 Sep 07;16:397. (PMID: 26346538)
Prim Care. 2014 Mar;41(1):75-90. (PMID: 24439882)
J Clin Periodontol. 2020 Jul;47 Suppl 22:4-60. (PMID: 32383274)
J Int Acad Periodontol. 1999 Oct;1(4):110-6. (PMID: 12666955)
Crit Care. 2013 Nov 08;17(6):R266. (PMID: 24207137)
Lancet. 2014 Jan 18;383(9913):267-76. (PMID: 24411647)
J Clin Periodontol. 2013 Apr;40 Suppl 14:S106-12. (PMID: 23627322)
J Clin Periodontol. 2017 Mar;44 Suppl 18:S94-S105. (PMID: 28266116)
J Dent. 2021 Mar;106:103562. (PMID: 33573801)
PLoS One. 2015 Jun 26;10(6):e0129514. (PMID: 26115172)
Cochrane Database Syst Rev. 2017 Mar 31;3:CD008676. (PMID: 28362061)
Complement Ther Med. 2014 Feb;22(1):75-80. (PMID: 24559820)
Periodontol 2000. 2012 Oct;60(1):15-39. (PMID: 22909104)
Int J Nurs Pract. 2012 Apr;18(2):188-94. (PMID: 22435983)
Am J Orthod Dentofacial Orthop. 2020 Nov;158(5):650-660. (PMID: 32950336)
Br J Surg. 2015 Oct;102(11):1360-71. (PMID: 26179938)
Braz J Phys Ther. 2016 Jan 19;20(2):105-13. (PMID: 26786084)
Lancet. 2018 Nov 10;392(10159):1789-1858. (PMID: 30496104)
Med Educ. 2006 Jan;40(1):43-50. (PMID: 16441322)
Cochrane Database Syst Rev. 2013 Dec 05;(12):CD010514. (PMID: 24310847)
Trials. 2017 Sep 20;18(1):436. (PMID: 28931440)
PLoS One. 2015 Mar 13;10(3):e0120568. (PMID: 25768435)
J Clin Periodontol. 2015 Apr;42 Suppl 16:S12-35. (PMID: 25495962)
J Clin Periodontol. 2021 Jun;48(6):859-866. (PMID: 33570217)
Trials. 2012 Jul 02;13:103. (PMID: 22747787)
J Int Acad Periodontol. 2020 Apr 1;22(2):41-53. (PMID: 32224549)
Int J Clin Pharm. 2016 Jun;38(3):655-62. (PMID: 26846316)
Cochrane Database Syst Rev. 2018 Dec 27;12:CD004625. (PMID: 30590875)
J Clin Periodontol. 2018 Jun;45 Suppl 20:S171-S189. (PMID: 29926486)
Cochrane Database Syst Rev. 2018 Oct 31;10:CD007447. (PMID: 30380139)
Grant Information:: HSRU1 United Kingdom CSO_ Chief Scientist Office
Entry Date(s):: Date Created: 20210722 Date Completed: 20211109 Latest Revision: 20231102
Update Code:: 20240105
PubMed Central ID:: PMC8297801
DOI:: 10.1371/journal.pone.0254123
PMID:: 34292965
: Czasopismo naukowe

Pełny tekst

Background: There is no agreement which outcomes should be measured when investigating interventions for periodontal diseases. It is difficult to compare or combine studies with different outcomes; resulting in research wastage and uncertainty for patients and healthcare professionals.
Objective: Develop a core outcome set (COS) relevant to key stakeholders for use in effectiveness trials investigating prevention and management of periodontal diseases.
Methods: Mixed method study involving literature review; online Delphi Study; and face-to-face consensus meeting.
Participants: Key stakeholders: patients, dentists, hygienist/therapists, periodontists, researchers.
Results: The literature review identified 37 unique outcomes. Delphi round 1: 20 patients and 51 dental professional and researchers prioritised 25 and suggested an additional 11 outcomes. Delphi round 2: from the resulting 36 outcomes, 13 patients and 39 dental professionals and researchers prioritised 22 outcomes. A face-to-face consensus meeting was hosted in Dundee, Scotland by an independent chair. Eight patients and six dental professional and researchers participated. The final COS contains: Probing depths, Quality of life, Quantified levels of gingivitis, Quantified levels of plaque, Tooth loss.
Conclusions: Implementation of this COS will ensure the results of future effectiveness trials for periodontal diseases are more relevant to patients and dental professionals, reducing research wastage. This could reduce uncertainty for patients and dental professionals by ensuring the evidence used to inform their choices is meaningful to them. It could also strengthen the quality and certainty of the evidence about the relative effectiveness of interventions.
Registration: COMET Database: http://www.comet-initiative.org/studies/details/265?result=true.
Competing Interests: The authors have declared that no competing interests exist.

Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Informacja