Fimbristylis ovata extract and its ability to encounter AGEs-induced neurotoxicity in SH-SY5Y.

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Tytuł:: Fimbristylis ovata extract and its ability to encounter AGEs-induced neurotoxicity in SH-SY5Y.
Autorzy:: Sirirattanakul S; Graduate Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330 Thailand.
Santiyanont R; Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330 Thailand.
Źródło:: Toxicological research [Toxicol Res] 2021 Jan 25; Vol. 37 (3), pp. 355-367. Date of Electronic Publication: 2021 Jan 25 (Print Publication: 2021).
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2020- : Singapore : Springer Singapore
Original Publication: Seoul : Korean Society of Toxicology
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Contributed Indexing:: Keywords: Fimbristylis ovata; Neurotoxicity; Oxidative stress; Pro-inflammatory cytokines; SH-SY5Y
Entry Date(s):: Date Created: 20210723 Latest Revision: 20220716
Update Code:: 20240105
PubMed Central ID:: PMC8249652
DOI:: 10.1007/s43188-020-00072-z
PMID:: 34295799
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Abstract: Advanced glycation end products (AGEs) upon binding to its receptor (receptor for AGEs, RAGE) trigger several pathological processes involving oxidative stress and inflammatory pathway which play a pivotal role in various degenerative diseases including Alzheimer's disease. Fimbristylis ovata ( F. ovata ) has long been reported to be used as a traditional herbal medicine; nonetheless, very few studies have been reported. In this study, the protective effects of F. ovata extract on neurotoxicity of hippocampal neuronal cells (SH-SY5Y) was investigated. When compared to normal control, AGEs treatment significantly induced oxidative stress level and enhanced NF-κB translocation to nucleus in the neuronal cells ( p < 0.05). The increase in NF-κB translocation leads to increase in transcription level of the target genes including RAGE and pro-inflammatory cytokines which include interleukin 1 beta (IL1B), tumor necrosis factor-alpha (TNFA) and interleukin 6 (IL6). Pre-treatment of SH-SY5Y with the extracts of F. ovata shows favorable results by significantly suppressing oxidative stress level ( p < 0.05) as well transcriptional level of RAGE ( p < 0.05) and pro-inflammatory cytokines ( p < 0.05). Chemical analysis of F. ovata extracts using High Resolution Liquid Chromatograph Mass Spectrometer (HR-LCMS) and Gas Chromatograph with high resolution Mass Spectrometer (GC-HRMS) suggested some potential active phytochemical compounds. The results from this study may provide possible alternative treatment for prevention and/or therapy of neurodegenerative disorders by targeting the above-mentioned pathways. The role of the phytochemical active ingredient (s) in inhibiting the AGEs-triggered signaling inflammatory pathway should be investigated in future study.
Competing Interests: Conflict of interestAll authors declare no conflict of interest to disclose.
(© Korean Society of Toxicology 2021.)

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