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Tytuł:
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Clitorienolactones and Isoflavonoids of Clitorea ternatea Roots Alleviate Stress-Like Symptoms in a Reserpine-Induced Zebrafish Model.
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Autorzy:
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Ngadni MA; Natural Medicines and Products Research Laboratory (NaturMeds), Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Malaysia.
Akhtar MT; Natural Medicines and Products Research Laboratory (NaturMeds), Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Malaysia.; Institute of Industrial Biotechnology, Government College University, Lahore 54000, Pakistan.
Ismail IS; Natural Medicines and Products Research Laboratory (NaturMeds), Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Malaysia.
Norazhar AI; Natural Medicines and Products Research Laboratory (NaturMeds), Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Malaysia.
Lee SY; Natural Medicines and Products Research Laboratory (NaturMeds), Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Malaysia.
Maulidiani M; Natural Medicines and Products Research Laboratory (NaturMeds), Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Malaysia.; School of Fundamental Science, University Malaysia Terengganu (UMT), Kuala Nerus 21030, Malaysia.
Shaari K; Natural Medicines and Products Research Laboratory (NaturMeds), Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Malaysia.
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Źródło:
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Molecules (Basel, Switzerland) [Molecules] 2021 Jul 07; Vol. 26 (14). Date of Electronic Publication: 2021 Jul 07.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Basel, Switzerland : MDPI, c1995-
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MeSH Terms:
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Clitoria/*chemistry
Depression/*drug therapy
Flavonoids/*pharmacology
Lactones/*pharmacology
Plant Extracts/*pharmacology
Plant Roots/*chemistry
Stress, Physiological/*drug effects
Animals ; Behavior, Animal ; Depression/chemically induced ; Isoflavones/pharmacology ; Reserpine/toxicity ; Zebrafish
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References:
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Contributed Indexing:
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Keywords: Clitorea ternatea; LCMS/MS; clitorienolactones; flavonoids; metabolite profile; novel tank test; reserpine-induced stress; zebrafish model
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Substance Nomenclature:
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0 (Flavonoids)
0 (Isoflavones)
0 (Lactones)
0 (Plant Extracts)
8B1QWR724A (Reserpine)
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Entry Date(s):
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Date Created: 20210724 Date Completed: 20210910 Latest Revision: 20210910
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Update Code:
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20240105
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PubMed Central ID:
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PMC8304078
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DOI:
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10.3390/molecules26144137
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PMID:
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34299411
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Clitorea ternatea has been used in Ayurvedic medicine as a brain stimulant to treat mental illnesses and mental functional disorders. In this study, the metabolite profiles of crude C. ternatea root extract (CTRE), ethyl acetate (EA), and 50% aqueous methanol (50% MeOH) fractions were investigated using ultrahigh-performance liquid chromatography-diode array detector-tandem mass spectrometry (UHPLC-DAD-MS/MS), while their effect on the stress-like behavior of zebrafish, pharmacologically induced with reserpine, was investigated. A total of 32 compounds were putatively identified, among which, a series of norneolignans, clitorienolactones, and various flavonoids (flavone, flavonol, isoflavone, and isoflavanone) was found to comprise the major constituents, particularly in the EA and 50% MeOH fractions. The clitorienolactones, presently unique to the species, were present in both the free and glycosylated forms in the roots. Both the EA and 50% MeOH fractions displayed moderate effects on the stress-induced zebrafish model, significantly decreasing freezing duration and elevating the total distance travelled and average velocity, 72 h post-treatment. The results of the present study provide further evidence that the basis for the use of C. ternatea roots in traditional medicine to alleviate brain-related conditions, such as stress and depression, is attributable to the presence of clitorienolactones and the isoflavonoidal constituents.
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