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Tytuł:
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New amide alkaloids and carbazole alkaloid from the stems of Clausena lansium.
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Autorzy:
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Sun X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Li C; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Ma J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Zang Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Huang J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Chen N; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Wang X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Zhang D; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: .
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Źródło:
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Fitoterapia [Fitoterapia] 2021 Oct; Vol. 154, pp. 104999. Date of Electronic Publication: 2021 Jul 22.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 1999- : [Amsterdam] : Elsevier
Original Publication: Milano : Inverni & Della Beffa S.p.A.
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MeSH Terms:
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Alkaloids/*pharmacology
Amides/*pharmacology
Carbazoles/*pharmacology
Clausena/*chemistry
Neuroprotective Agents/*pharmacology
Alkaloids/isolation & purification ; Amides/isolation & purification ; Animals ; Carbazoles/isolation & purification ; China ; Molecular Structure ; Neuroprotective Agents/isolation & purification ; PC12 Cells ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Stems/chemistry ; Rats
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Contributed Indexing:
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Keywords: Amide alkaloids; Carbazole alkaloid; Clausena lansium; Neuroprotection
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Substance Nomenclature:
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0 (Alkaloids)
0 (Amides)
0 (Carbazoles)
0 (Neuroprotective Agents)
0 (Phytochemicals)
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Entry Date(s):
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Date Created: 20210724 Date Completed: 20211014 Latest Revision: 20211014
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Update Code:
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20240105
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DOI:
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10.1016/j.fitote.2021.104999
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PMID:
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34302918
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Five unreported alkaloids including four amide alkaloids (1a, 2a, 3a, and 3b) and one carbazole alkaloid (4) with two known compounds (1b, 2b) were obtained from the stems of Clausena lansium. Their structures were demonstrated by spectroscopic experiments. And the absolute configurations of compounds 1a, 1b, 2b, and 3b were determined by single X-ray diffraction analysis. The neuroprotection assay showed that compound 4 had moderate inhibition effect on PC12 cells induced by serum withdrawal at the concentration of 10 μM. And compounds 1a and 4 had weak protective effects on primary neurons against oxygen glucose deprivation injury at the concentration of 10 μM.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
