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Tytuł:
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(±)-Involucrasins A and B, two pairs of flavanone enantiomers from Shuteria involucrata and their inhibitory effects on the proliferation of various cancer cell lines.
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Autorzy:
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Liu L; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Li XH; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Ma XX; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Tan WH; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Ma WZ; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Shen YF; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Khan A; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Zhou ZH; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Yang ZY; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
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Źródło:
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Journal of Asian natural products research [J Asian Nat Prod Res] 2022 Jul; Vol. 24 (7), pp. 641-647. Date of Electronic Publication: 2021 Jul 24.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: London : Informa Healthcare
Original Publication: [Newark, N.J.?] : Harwood Academic Publishers,
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MeSH Terms:
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Flavanones*/chemistry
Flavanones*/pharmacology
Neoplasms*
Caco-2 Cells ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Inhibitory Concentration 50 ; Molecular Structure
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Contributed Indexing:
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Keywords: Shuteria involucrata; cytotoxic activity; flavanone enantiomers; involucrasin A; involucrasin B; natural; products
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Substance Nomenclature:
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0 (Flavanones)
WX22P730FB (flavanone)
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Entry Date(s):
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Date Created: 20210726 Date Completed: 20220613 Latest Revision: 20220613
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Update Code:
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20240105
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DOI:
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10.1080/10286020.2021.1952187
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PMID:
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34304657
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(±)-Involucrasins A ( 1 ) and B ( 2 ), two pairs of flavanone enantiomers were isolated from Shuteria involucrata . Structurally, both 1 and 2 are rare representatives of 5-dehydroxy/5-demethoxy 2',3',4'-trisubstituted flavanones. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis and comparison with the literature data. Involucrasin B ( 2 ) exhibited moderate anti-proliferative activity against Caco-2, MCF-7, MDA-MB-468, and HCT116 cell lines with IC 50 values ranging from 7.9-22.7 μM. Involucrasin A ( 1 ) exhibited weak inhibitory activity against Caco-2 and MCF-7 cell lines with IC 50 values of 25.8 and 26.5 μM, respectively.
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